Concepedia

Substitution Matrices

Substitution Matrices is a matrix-based scoring function in sequence analysis that assigns quantitative scores or probabilities to all possible substitutions between sequence symbols (such as nucleotides or amino acids), typically derived from empirical substitution frequencies or evolutionary models, for use in sequence comparison and alignment algorithms.

234

Publications

76.3K

Citations

465

Authors

296

Institutions

Publications per year

2017–2026

21

Variants

Substitution Matrix

Parents

Children

Publications

234

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

Journal of Molecular Evolution · 1980 · 29.8K citations

, , +15

The rapid generation of mutation data matrices from protein sequences

David T. Jones, William R. Taylor, Janet M. Thornton · Computer applications in the biosciences · 1992 · 7.1K citations

, , +10

Amino acid substitution matrices from protein blocks.

Steven Henikoff, Jorja G. Henikoff · Proceedings of the National Academy of Sciences · 1992 · 6.4K citations

, , +16

An Improved General Amino Acid Replacement Matrix

Si Quang Le, Olivier Gascuel · Molecular Biology and Evolution · 2008 · 3.3K citations · Full text

, , +17

Predicting Deleterious Amino Acid Substitutions

Pauline C. Ng, Steven Henikoff · Genome Research · 2001 · 2.7K citations · Full text

, , +15

1–5 of 234

Authors

465

  1. SQ
    Si Quang Le

    Wellcome Sanger Institute, United Kingdom

    5 publications · 3.9K citations

    5

    h-index

  2. OG
    Olivier Gascuel

    Centre National de la Recherche Scientifique, France

    5 publications · 3.9K citations

    5

    h-index

  3. SH
    Steven Henikoff

    Fred Hutch Cancer Center, United States

    5 publications · 9.9K citations

    5

    h-index

  4. GH
    Gastón H. Gonnet

    ETH Zurich, Switzerland

    4 publications · 330 citations

    4

    h-index

  5. JG
    Jorja G. Henikoff

    Fred Hutch Cancer Center, United States

    4 publications · 7.2K citations

    4

    h-index

1–5 of 465

Institutions

296

  1. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    18 publications

    8.2K citations

  2. National Institutes of Health

    Bethesda, United States

    6 h-index

    11 publications

    1.3K citations

  3. Université de Montpellier

    Montpellier, France

    6 h-index

    16 publications

    8.1K citations

  4. Fred Hutch Cancer Center

    Seattle, United States

    5 h-index

    10 publications

    7.3K citations

  5. SIB Swiss Institute of Bioinformatics

    Lausanne, Switzerland

    4 h-index

    6 publications

    146 citations

  6. The University of Texas Health Science Center at Houston

    Houston, United States

    4 h-index

    7 publications

    190 citations

  7. Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier

    Montpellier, France

    4 h-index

    8 publications

    7.9K citations

  8. Australian National University

    Canberra, Australia

    4 h-index

    7 publications

    392 citations

1–8 of 296

Venues

  1. Journal of Molecular Evolution

    27 publications · 34.9K citations

    21

    h-index

  2. Molecular Biology and Evolution

    MBE · 18 publications · 10K citations

    17

    h-index

  3. Bioinformatics

    17 publications · 764 citations

    13

    h-index

  4. BMC Bioinformatics

    18 publications · 643 citations

    13

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 5 publications · 477 citations

    5

    h-index

1–5