Concepedia

Structure-based Enzyme Design

Structure-Based Enzyme Design is a computational and experimental methodology in structural enzymology that uses the three-dimensional atomic structure of an enzyme as the foundational framework to rationally engineer or de novo design catalytic function with enhanced or novel biochemical properties.

133

Publications

9.8K

Citations

721

Authors

257

Institutions

Publications per year

2017–2026

34

Parents

Publications

133

De Novo Computational Design of Retro-Aldol Enzymes

Lin Jiang, Eric A. Althoff, Fernando R. Clemente et al. · Science · 2008 · 1.2K citations

, , +17

Enzyme-like proteins by computational design

Daniel N. Bolon, Stephen L. Mayo · Proceedings of the National Academy of Sciences · 2001 · 412 citations · Full text

, , +17

RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality

Stephen W. Santoro, Gerald F. Joyce, Kandasamy Sakthivel et al. · Journal of the American Chemical Society · 2000 · 358 citations

, , +17

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

Greg Winter, Alan R. Fersht, Anthony J. Wilkinson et al. · Nature · 1982 · 356 citations

, , +17

Iterative approach to computational enzyme design

Heidi K. Privett, Gert Kiss, Toni M. Lee et al. · Proceedings of the National Academy of Sciences · 2012 · 338 citations · Full text

, , +16

1–5 of 133

Authors

721

  1. DB
    David Baker

    University of Washington, United States

    5 publications · 1.5K citations

    5

    h-index

  2. KN
    K. N. Houk

    University of California, Los Angeles, United States

    4 publications · 1.7K citations

    4

    h-index

  3. DH
    Donald Hilvert

    ETH Zurich, Switzerland

    3 publications · 1.6K citations

    3

    h-index

  4. DB
    Douglas B. Jordan

    DuPont (United States), United States

    3 publications · 136 citations

    3

    h-index

  5. SJ
    Sarel J. Fleishman

    Weizmann Institute of Science, Israel

    3 publications · 234 citations

    3

    h-index

1–5 of 721

Institutions

257

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    32 publications

    19.5K citations

  2. University of Washington

    Seattle, United States

    6 h-index

    29 publications

    18.3K citations

  3. University of California, Los Angeles

    Los Angeles, United States

    5 h-index

    26 publications

    17.9K citations

  4. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    12 publications

    828 citations

  5. University of California, San Francisco

    San Francisco, United States

    3 h-index

    20 publications

    3.1K citations

  6. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    20 publications

    1.4K citations

  7. Universidade de São Paulo

    São Paulo, Brazil

    2 h-index

    8 publications

    360 citations

  8. Korea Advanced Institute of Science and Technology

    Daejeon, South Korea

    2 h-index

    7 publications

    201 citations

1–8 of 257

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    7 publications · 182 citations

    7

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 1.6K citations

    7

    h-index

  3. Journal of Molecular Biology

    JMB · 7 publications · 574 citations

    7

    h-index

  4. Journal of Molecular Graphics and Modelling

    6 publications · 197 citations

    6

    h-index

  5. Nature Communications

    4 publications · 259 citations

    4

    h-index

1–5