Concepedia

Sequence-function Inference

Sequence-Function Inference is a computational or statistical method that, within the context of genotype-phenotype coupling, identifies the relationship between biological sequence variants and their functional phenotypic outcomes by modeling how specific nucleotide or amino acid changes give rise to observable molecular or cellular functions.

44

Publications

3.5K

Citations

256

Authors

103

Institutions

Publications per year

2017–2026

25

Parents

Publications

44

Language models enable zero-shot prediction of the effects of mutations on protein function

Joshua Meier, Roshan Rao, Robert Verkuil et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 670 citations · Full text

, , +17

Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity

Eric A. Stone, Arend Sidow · Genome Research · 2005 · 428 citations · Full text

, , +13

Generating functional protein variants with variational autoencoders

Alex Hawkins‐Hooker, Florence Depardieu, Sebastien Baur et al. · PLoS Computational Biology · 2021 · 202 citations · Full text

, , +10

ECNet is an evolutionary context-integrated deep learning framework for protein engineering

Yunan Luo, Guangde Jiang, Tianhao Yu et al. · Nature Communications · 2021 · 186 citations · Full text

, , +13

Translocation in yeast and mammalian cells: not all signal sequences are functionally equivalent.

Phillip I. Bird, M J Gething, Joseph Sambrook · The Journal of Cell Biology · 1987 · 125 citations · Full text

, , +17

1–5 of 44

Authors

256

  1. PA
    Philip A. Romero

    University of Wisconsin–Madison, United States

    3 publications · 106 citations

    3

    h-index

  2. CR
    Chase R. Freschlin

    University of Wisconsin–Madison, United States

    3 publications · 106 citations

    3

    h-index

  3. DB
    David Bikard

    Institut Pasteur, France

    2 publications · 236 citations

    2

    h-index

  4. JM
    Joshua Moller

    University of Chicago, United States

    2 publications · 47 citations

    2

    h-index

  5. SD
    Sameer D’Costa

    University of Wisconsin–Madison, United States

    2 publications · 62 citations

    2

    h-index

1–5 of 256

Institutions

103

  1. University of Illinois Urbana-Champaign

    Urbana, United States

    4 h-index

    23 publications

    3K citations

  2. University of Wisconsin–Madison

    Madison, United States

    4 h-index

    22 publications

    758 citations

  3. University of California, Berkeley

    Berkeley, United States

    3 h-index

    21 publications

    1.7K citations

  4. University of California San Diego

    San Diego, United States

    3 h-index

    5 publications

    408 citations

  5. Duke University

    Durham, United States

    2 h-index

    2 publications

    62 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    5 publications

    294 citations

  7. Weizmann Institute of Science

    Rehovot, Israel

    2 h-index

    8 publications

    335 citations

  8. Nvidia (United States)

    Santa Clara, United States

    2 h-index

    8 publications

    188 citations

1–8 of 103

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 5 publications · 779 citations

    5

    h-index

  2. Nature Communications

    4 publications · 389 citations

    4

    h-index

  3. Bioinformatics

    3 publications · 169 citations

    3

    h-index

  4. PLoS Computational Biology

    2 publications · 223 citations

    2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 62 citations

    2

    h-index

1–5