Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences

Alexander Rives, Joshua Meier, Tom Sercu, +8

Proceedings of the National Academy of Sciences

Language models enable zero-shot prediction of the effects of mutations on protein function

Joshua Meier, Roshan Rao, Robert Verkuil, +3

Structured PredictionEngineeringMachine LearningGeneticsMolecular Biology +19

Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences

Alexander Rives, Joshua Meier, Tom Sercu, +8

Artificial IntelligenceEngineeringAmino AcidsStructural BioinformaticsMolecular Biology +19

Transformer protein language models are unsupervised structure learners

Roshan Rao, Joshua Meier, Tom Sercu, +2

Structured PredictionEngineeringStructural BioinformaticsContact PredictionMolecular Biology +18

MSA Transformer

Roshan Rao, Jason Liu, Robert Verkuil, +5

Natural Language ProcessingSequence ModellingEngineeringNatural SciencesComputational Linguistics +11

GUIDES: sgRNA design for loss-of-function screens

Joshua Meier, Feng Zhang, Neville E. Sanjana

Nature Methods

EngineeringElectronic Design AutomationComputational BiologyComputer EngineeringSgrna Design +3

Evaluating Reinforcement Learning Algorithms in Observational Health Settings

Omer Gottesman, Fredrik Johansson, Joshua Meier, +12

arXiv (Cornell University)

Artificial IntelligenceEngineeringMachine LearningHealth PolicyData Science +10

A Lymphotoxin-IFN-β Axis Essential for Lymphocyte Survival Revealed during Cytomegalovirus Infection

Theresa A. Banks, Sandra Rickert, Chris A. Benedict, +15

The Journal of Immunology

Unlocking <i>de novo</i> antibody design with generative artificial intelligence

Amir Shanehsazzadeh, Matt McPartlon, George W. Kasun, +46

Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness

Sharrol Bachas, Goran Rakočević, David A. Spencer, +30

EngineeringArtificial Immune SystemImmunologyImmunological ComputingAntibody Variants +15