Concepedia

Selectivity Profile Optimization

Selectivity Profile Optimization is a systematic methodology in multi-target drug design that refines a compound's binding affinity landscape to maximize therapeutic efficacy by enhancing target-specific interactions while minimizing off-target effects.

120

Publications

5.1K

Citations

1.3K

Authors

265

Institutions

Publications per year

2017–2026

37

Parents

Publications

120

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

Timothy A. Whitehead, Aaron Chevalier, Yifan Song et al. · Nature Biotechnology · 2012 · 386 citations · Full text

, , +14

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876

Hölger Siebeneicher, Arwed Cleve, Hartmut Rehwinkel et al. · ChemMedChem · 2016 · 273 citations · Full text

, , +14

Ligand-Controlled Regiodivergent Ni-Catalyzed Reductive Carboxylation of Allyl Esters with CO<sub>2</sub>

Toni Moragas, Josep Cornellà, Rubén Martı́n · Journal of the American Chemical Society · 2014 · 194 citations

, , +11

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-<i>N</i>-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1<i>H</i>-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Mimi L. Quan, Patrick Y. S. Lam, Qi Han et al. · Journal of Medicinal Chemistry · 2004 · 189 citations · Full text

, , +12

Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells

Linda Marek, Alexandra Hamacher, Finn K. Hansen et al. · Journal of Medicinal Chemistry · 2012 · 182 citations · Full text

, , +11

1–5 of 120

Authors

1.3K

  1. MT
    Masaaki Toda

    Ono Pharmaceutical (Japan), Japan

    3 publications · 51 citations

    3

    h-index

  2. HN
    Hisao Nakai

    Ono Pharmaceutical (Japan), Japan

    3 publications · 51 citations

    3

    h-index

  3. FK
    Finn K. Hansen

    Heinrich Heine University Düsseldorf, Germany

    3 publications · 245 citations

    3

    h-index

  4. KK
    Kigen Kondo

    Ono Pharmaceutical (Japan), Japan

    3 publications · 51 citations

    3

    h-index

  5. YL
    Yichin Liu

    WuXi AppTec (China), China

    3 publications · 130 citations

    3

    h-index

1–5 of 1.3K

Institutions

265

  1. WuXi AppTec (China)

    Shanghai, China

    5 h-index

    12 publications

    421 citations

  2. Novartis (Switzerland)

    Basel, Switzerland

    4 h-index

    20 publications

    748 citations

  3. Pfizer (United States)

    New York, United States

    4 h-index

    55 publications

    798 citations

  4. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    4 h-index

    49 publications

    2K citations

  5. Amgen (United States)

    Thousand Oaks, United States

    4 h-index

    51 publications

    2.8K citations

  6. University of Naples Federico II

    Naples, Italy

    3 h-index

    7 publications

    413 citations

  7. Scripps Research Institute

    San Diego, United States

    3 h-index

    15 publications

    1.4K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    15 publications

    633 citations

1–8 of 265

Venues

  1. Journal of Medicinal Chemistry

    30 publications · 1.7K citations

    23

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    14 publications · 360 citations

    12

    h-index

  3. ACS Medicinal Chemistry Letters

    11 publications · 544 citations

    11

    h-index

  4. Bioorganic & Medicinal Chemistry

    9 publications · 195 citations

    8

    h-index

  5. ChemMedChem

    5 publications · 355 citations

    5

    h-index

1–5