Timothy A. Whitehead

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

Sarel J. Fleishman, Timothy A. Whitehead, Damian C. Ekiert et al. · Science · 2011 · 594 citations

Conserved Surface Patch, Protein Assembly, Synthetic Virology +19

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

Timothy A. Whitehead, Aaron Chevalier, Yifan Song et al. · Nature Biotechnology · 2012 · 379 citations · Full text

Drug Target, Influenza Inhibitors, Engineering +11

Plasmid-based one-pot saturation mutagenesis

Emily E. Wrenbeck, Justin R. Klesmith, James A. Stapleton et al. · Nature Methods · 2016 · 190 citations · Full text

Engineering, Biotechnology, Genetic Engineering +4

Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning

Justin R. Klesmith, J.P. Bacik, Emily E. Wrenbeck et al. · Proceedings of the National Academy of Sciences · 2017 · 164 citations · Full text

Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded

Emily E. Wrenbeck, Laura R. Azouz, Timothy A. Whitehead · Nature Communications · 2017 · 162 citations · Full text