A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Thorlákur Jónsson, Jasvinder K. Atwal, Stacy Steinberg, +22

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseAgingApp ProtectsGenetics +8

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

Yichin Liu, Lara Fallon, Hilal A. Lashuel, +2

Cell

Disease SusceptibilityNeurodegenerative DiseasesMolecular NeuroscienceDisease MechanismSynaptic Signaling +10

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

Maia Vinogradova, Victor Gehling, Amy Gustafson, +32

Nature Chemical Biology

Drug-tolerant Cancer CellsMedicineAnti-cancer AgentTumor SuppressorCancer Treatment +5

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

Jasvinder K. Atwal, Yongmei Chen, Cecilia Chiu, +17

Science Translational Medicine

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

Yichin Liu, Hilal A. Lashuel, Sung‐Woon Choi, +7

Chemistry & Biology

Oncogenic AgentMedicineCancer BiologyAnti-cancer AgentTumor Suppressor +6

Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein

Janice Maloney, Travis W. Bainbridge, Amy Gustafson, +8

Journal of Biological Chemistry

Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates

Niña G. Caculitan, Josefa Chuh, Yong Ma, +12

Cancer Research

Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

Zhihua Liu, Robin K. Meray, Tom N. Grammatopoulos, +5

Proceedings of the National Academy of Sciences

MitophagyUbiquitin C-terminal Hydrolase-l1Expression PatternSynaptic SignalingAutophagy +14

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Rachana Ohri, Sunil Bhakta, Aimee Fourie-O’Donohue, +17

Bioconjugate Chemistry

Molecular BiologyImmunochemistryAntibody EngineeringDisulfide-based LinkersVitro Plasma Stabilities +14

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

BinQing Wei, Janet Gunzner-Toste, Hui Yao, +30

Journal of Medicinal Chemistry

Peptide EngineeringImmunologyPeptide ScienceImmunotherapyEnhanced Protease Specificity +15