Concepedia

Regulatory T Cell Dysfunction

Regulatory T Cell Dysfunction is an immunopathological state of FOXP3⁺ CD4⁺ regulatory T lymphocytes characterized by quantitative or qualitative defects in their development, stability, or suppressive function that compromise immune tolerance and thereby promote or fail to control autoimmune responses.

1.5K

Publications

116K

Citations

10.7K

Authors

2.1K

Institutions

Publications per year

2017–2026

479

Variants

Treg Dysfunction

Parents

Children

Publications

1.5K

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell et al. · Nature Genetics · 2001 · 3.4K citations

, , +13

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

, , +14

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Vissia Viglietta, Clare Baecher‐Allan, Howard L. Weiner et al. · The Journal of Experimental Medicine · 2004 · 1.8K citations · Full text

, , +17

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

Xuyu Zhou, Samantha L. Bailey-Bucktrout, Lukas T. Jeker et al. · Nature Immunology · 2009 · 1.3K citations · Full text

, , +14

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

Giovanna Borsellino, Markus Kleinewietfeld, Diletta Di Mitri et al. · Blood · 2007 · 1.3K citations · Full text

, , +13

1–5 of 1.5K

Authors

10.7K

  1. CB
    Christophe Benoıst

    Harvard University, United States

    12 publications · 1.6K citations

    12

    h-index

  2. RB
    Rosa Bacchetta

    The San Raffaele Telethon Institute for Gene Therapy, Italy

    11 publications · 1.4K citations

    11

    h-index

  3. DM
    Diane Mathis

    Harvard University, United States

    11 publications · 1.6K citations

    11

    h-index

  4. TS
    Tim Sparwasser

    Center for Experimental and Clinical Infection Research, Germany

    10 publications · 1.9K citations

    10

    h-index

  5. KC
    Kari C. Nadeau

    Stanford University, United States

    10 publications · 1.5K citations

    10

    h-index

1–5 of 10.7K

Institutions

2.1K

  1. Harvard University

    Cambridge, United States

    41 h-index

    230 publications

    39.4K citations

  2. Brigham and Women's Hospital

    Boston, United States

    32 h-index

    114 publications

    40.6K citations

  3. Inserm

    Paris, France

    31 h-index

    330 publications

    22.7K citations

  4. National Institutes of Health

    Bethesda, United States

    27 h-index

    152 publications

    32.6K citations

  5. Stanford University

    Stanford, United States

    26 h-index

    149 publications

    17.6K citations

  6. University of Pennsylvania

    Philadelphia, United States

    25 h-index

    109 publications

    14.4K citations

  7. Heidelberg University

    Heidelberg, Germany

    24 h-index

    159 publications

    12.4K citations

  8. Huazhong University of Science and Technology

    Wuhan, China

    23 h-index

    274 publications

    11K citations

1–8 of 2.1K

Venues

  1. The Journal of Immunology

    JI · 67 publications · 7.2K citations

    46

    h-index

  2. Blood

    40 publications · 7.8K citations

    32

    h-index

  3. Journal of Allergy and Clinical Immunology

    28 publications · 4.2K citations

    27

    h-index

  4. Clinical Immunology

    36 publications · 2.8K citations

    27

    h-index

  5. Frontiers in Immunology

    42 publications · 2K citations

    25

    h-index

1–5