Concepedia

Foxp3 Deficiency

FOXP3 Deficiency is a molecular pathogenic condition characterized by loss-of-function mutations in the FOXP3 gene, a master transcriptional regulator of regulatory T cell development and function, leading to unchecked immune activation and autoimmune manifestations.

568

Publications

82K

Citations

4K

Authors

988

Institutions

Publications per year

2017–2026

136

Parents

Publications

568

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8.1K citations

, , +17

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot, Marc A. Gavin, Alexander Y. Rudensky · Nature Immunology · 2003 · 7.7K citations

, , +14

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell et al. · Nature Genetics · 2001 · 3.4K citations

, , +13

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Jason D. Fontenot, Jeffrey P. Rasmussen, Marc A. Gavin et al. · Nature Immunology · 2005 · 1.8K citations

, , +14

Foxp3<sup>+</sup>CD25<sup>+</sup>CD4<sup>+</sup> natural regulatory T cells in dominant self‐tolerance and autoimmune disease

Shimon Sakaguchi, Masahiro Ono, Ruka Setoguchi et al. · Immunological Reviews · 2006 · 1.5K citations · Full text

, , +17

1–5 of 568

Authors

4K

  1. AY
    Alexander Y. Rudensky

    Howard Hughes Medical Institute, United States

    18 publications · 13.9K citations

    18

    h-index

  2. TS
    Tim Sparwasser

    Center for Experimental and Clinical Infection Research, Germany

    15 publications · 2.4K citations

    15

    h-index

  3. DM
    Diane Mathis

    Harvard University, United States

    15 publications · 1.5K citations

    15

    h-index

  4. CB
    Christophe Benoıst

    Harvard University, United States

    14 publications · 1.4K citations

    14

    h-index

  5. RB
    Rosa Bacchetta

    The San Raffaele Telethon Institute for Gene Therapy, Italy

    13 publications · 1.4K citations

    13

    h-index

1–5 of 4K

Institutions

988

  1. Harvard University

    Cambridge, United States

    31 h-index

    150 publications

    20.6K citations

  2. University of Washington

    Seattle, United States

    30 h-index

    81 publications

    52K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    21 h-index

    47 publications

    40.9K citations

  4. Inserm

    Paris, France

    20 h-index

    168 publications

    12.7K citations

  5. National Institutes of Health

    Bethesda, United States

    18 h-index

    104 publications

    23K citations

  6. University of Pennsylvania

    Philadelphia, United States

    17 h-index

    84 publications

    9.7K citations

  7. Brigham and Women's Hospital

    Boston, United States

    17 h-index

    69 publications

    13.8K citations

  8. Center for Experimental and Clinical Infection Research

    Hanover, Germany

    14 h-index

    41 publications

    3.6K citations

1–8 of 988

Venues

  1. The Journal of Immunology

    JI · 53 publications · 6K citations

    37

    h-index

  2. Blood

    20 publications · 3.8K citations

    20

    h-index

  3. The Journal of Experimental Medicine

    20 publications · 4.8K citations

    19

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 3.4K citations

    17

    h-index

  5. Frontiers in Immunology

    15 publications · 868 citations

    14

    h-index

1–5