Concepedia

Receptor-mediated Toxicity

Receptor-Mediated Toxicity is a toxicodynamic mechanism of chemically induced adverse effects in which a xenobiotic elicits toxicity primarily through specific, high‑affinity interaction with cellular receptors, causing aberrant activation or inhibition of receptor-dependent signaling and gene-regulatory pathways that disrupt normal physiological homeostasis.

674

Publications

41.7K

Citations

3.1K

Authors

916

Institutions

Publications per year

2017–2026

141

Variants

Receptor-mediated Toxicodynamics

Parents

Children

Publications

674

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Alan Poland, Edward Glover, Andrew S. Kende · Journal of Biological Chemistry · 1976 · 1.4K citations · Full text

, , +17

Aryl-hydrocarbon Receptor-Deficient Mice Are Resistant to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity

Pedro M. Fernández‐Salguero, David M. Hilbert, Stuart Rudikoff et al. · Toxicology and Applied Pharmacology · 1996 · 848 citations

, , +8

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

Chihaya Imai, Keichiro Mihara, Martin Andreánsky et al. · Leukemia · 2004 · 830 citations

, , +10

Humanized xenobiotic response in mice expressing nuclear receptor SXR

Wen Xie, Joyce L. Barwick, Michael Downes et al. · Nature · 2000 · 657 citations

, , +12

Loss of teratogenic response to 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin (TCDD) in mice lacking the Ah (dioxin) receptor

Junsei Mimura, Keisuke Yamashita, Kenji Nakamura et al. · Genes to Cells · 1997 · 625 citations · Full text

, , +14

1–5 of 674

Authors

3.1K

  1. RP
    Raimo Pohjanvirta

    University of Helsinki, Finland

    17 publications · 935 citations

    16

    h-index

  2. AB
    Allan B. Okey

    University of Toronto, Canada

    15 publications · 1.2K citations

    14

    h-index

  3. MS
    Michael S. Denison

    University of California, Davis, United States

    9 publications · 779 citations

    9

    h-index

  4. EG
    Edward Glover

    University of Wisconsin–Madison, United States

    8 publications · 2.5K citations

    8

    h-index

  5. ME
    Mark E. Hahn

    Woods Hole Oceanographic Institution, United States

    8 publications · 434 citations

    8

    h-index

1–5 of 3.1K

Institutions

916

  1. University of Toronto

    Toronto, Canada

    17 h-index

    47 publications

    3.9K citations

  2. National Institutes of Health

    Bethesda, United States

    16 h-index

    42 publications

    6K citations

  3. University of Wisconsin–Madison

    Madison, United States

    15 h-index

    58 publications

    6.5K citations

  4. University of California, Davis

    Davis, United States

    14 h-index

    35 publications

    2.7K citations

  5. National Cancer Institute

    Bethesda, United States

    13 h-index

    25 publications

    6.2K citations

  6. Karolinska Institutet

    Stockholm, Sweden

    12 h-index

    34 publications

    1.7K citations

  7. Environmental Protection Agency

    Washington, United States

    12 h-index

    38 publications

    5.4K citations

  8. University of Helsinki

    Helsinki, Finland

    12 h-index

    20 publications

    620 citations

1–8 of 916

Venues

  1. Toxicological Sciences

    44 publications · 3.8K citations

    30

    h-index

  2. Toxicology and Applied Pharmacology

    TAAP · 48 publications · 3.4K citations

    30

    h-index

  3. Journal of Biological Chemistry

    JBC · 28 publications · 4.7K citations

    23

    h-index

  4. Environmental Science & Technology

    23 publications · 1.2K citations

    19

    h-index

  5. Environmental Health Perspectives

    EHP · 19 publications · 1.7K citations

    16

    h-index

1–5