Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

Chihaya Imai, Keichiro Mihara, Martin Andreánsky, +4

Leukemia

Hematological MalignancyMixed-phenotype Acute LeukemiaMalignant Blood DisorderAcute Lymphoblastic LeukemiaImmunology +7

Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells

Chihaya Imai, Shotaro Iwamoto, Dario Campana

Blood

Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy

Hiroyuki Fujisaki, Harumi Kakuda, Noriko Shimasaki, +6

Cancer Research

Hematological MalignancyCell TherapyCancer ImmunosurveillanceMedicineMalignant Blood Disorder +13

T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing

Ko Kudo, Chihaya Imai, Paolo Alberto Lorenzini, +5

Cancer Research

Gastric Cancer CellsAdaptive Immune SystemImmunologyImmune RegulationImmunodominance +18

Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15

Masaru Imamura, David Shook, Takahiro Kamiya, +5

Blood

Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase

Keichiro Mihara, Chihaya Imai, Elaine Coustan‐Smith, +4

British Journal of Haematology

Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations

Charline Miot, Kohsuke Imai, Chihaya Imai, +43

Blood

Replicative potential of human natural killer cells

Hiroyuki Fujisaki, Harumi Kakuda, Chihaya Imai, +2

British Journal of Haematology

Human CellHuman Nk CellsMedicineT-regulatory CellImmunology +10

Synthetic Messenger RNA as a Tool for Gene Therapy

P Rabinovich, Marina E. Komarovskaya, Zhijia Ye, +4

Human Gene Therapy

ImmunologyMolecular BiologyCancer VaccinesAntisense TherapyEfficient Vectorfree Method +14

All‐trans retinoic acid enhances cytotoxic effect of T cells with an anti‐CD38 chimeric antigen receptor in acute myeloid leukemia

Tetsumi Yoshida, Keichiro Mihara, Yoshifumi Takei, +7

Clinical & Translational Immunology