Concepedia

Rational Strain Design

Rational Strain Design is a systematic methodology in microbial metabolic engineering that employs prior biochemical and genomic knowledge to precisely engineer microbial strains through targeted genetic modifications, distinguishing it from random or empirical strain improvement approaches.

41

Publications

2.1K

Citations

217

Authors

86

Institutions

Publications per year

2017–2026

17

Parents

Publications

41

In silico design and adaptive evolution of <i>Escherichia coli</i> for production of lactic acid

Stephen S. Fong, Anthony P. Burgard, Christopher D. Herring et al. · Biotechnology and Bioengineering · 2005 · 366 citations

, , +17

Rational strain engineering in delafossite oxides for highly efficient hydrogen evolution catalysis in acidic media

Filip Podjaski, Daniel Weber, Siyuan Zhang et al. · Nature Catalysis · 2019 · 201 citations · Full text

, , +16

Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in <i>Escherichia coli</i>

Christine Nicole S. Santos, Wenhai Xiao, Gregory Stephanopoulos · Proceedings of the National Academy of Sciences · 2012 · 147 citations

, , +17

An evolutionary strategy for isobutanol production strain development in Escherichia coli

Kevin M. Smith, James C. Liao · Metabolic Engineering · 2011 · 120 citations

, , +16

Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus

Rongfeng Li, Craig A. Townsend · Metabolic Engineering · 2006 · 101 citations

, , +17

1–5 of 41

Authors

217

  1. SN
    Stephan Noack

    Forschungszentrum Jülich, Germany

    3 publications · 60 citations

    3

    h-index

  2. DM
    Daniel Machado

    University of Minho, Portugal

    2 publications · 164 citations

    2

    h-index

  3. JW
    Jianping Wen

    Tianjin University, China

    2 publications · 95 citations

    2

    h-index

  4. IR
    Isabel Rocha

    University of Minho, Portugal

    2 publications · 164 citations

    2

    h-index

  5. LM
    Ljubiša Mišković

    École Polytechnique Fédérale de Lausanne, Switzerland

    2 publications · 47 citations

    2

    h-index

1–5 of 217

Institutions

86

  1. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    3 h-index

    10 publications

    590 citations

  2. Forschungszentrum Jülich

    Jülich, Germany

    3 h-index

    21 publications

    402 citations

  3. Tianjin University

    Tianjin, China

    2 h-index

    8 publications

    427 citations

  4. Novo Nordisk Foundation

    Copenhagen, Denmark

    2 h-index

    3 publications

    164 citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    7 publications

    733 citations

  6. Technical University of Denmark

    Kongens Lyngby, Denmark

    2 h-index

    9 publications

    386 citations

  7. Korea Advanced Institute of Science and Technology

    Daejeon, South Korea

    2 h-index

    9 publications

    145 citations

  8. University of Minho

    Braga, Portugal

    2 h-index

    6 publications

    476 citations

1–8 of 86

Venues

  1. Metabolic Engineering

    6 publications · 345 citations

    6

    h-index

  2. Microorganisms

    2 publications · 46 citations

    2

    h-index

  3. Biotechnology and Bioengineering

    2 publications · 378 citations

    2

    h-index

  4. Applied and Environmental Microbiology

    AEM · 2 publications · 83 citations

    2

    h-index

  5. PLoS ONE

    2 publications · 95 citations

    2

    h-index

1–5