Concepedia

Proteolytic Pathway Analysis

Proteolytic Pathway Analysis is a methodological framework within activity-based protein profiling that specifically identifies and characterizes the functional dynamics of proteolytic cascades by selectively labelling active proteases and mapping their substrate cleavage events in complex biological systems.

151

Publications

9K

Citations

947

Authors

343

Institutions

Publications per year

2017–2026

31

Parents

Publications

151

The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage

Morten Nielsen, Claus Lundegaard, Ole Lund et al. · Immunogenetics · 2005 · 493 citations

, , +16

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

Ajay A. Vashisht, Kimberly B. Zumbrennen, Xinhua Huang et al. · Science · 2009 · 431 citations · Full text

, , +16

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Lisa Sevenich, Robert L. Bowman, Steven D. Mason et al. · Nature Cell Biology · 2014 · 377 citations · Full text

, , +16

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

Oded Kleifeld, Alain Doucet, Anna Prudova et al. · Nature Protocols · 2011 · 327 citations

, , +16

Dynamics of proteasome distribution in living cells

Eric A. Reits · The EMBO Journal · 1997 · 274 citations

, , +13

1–5 of 151

Authors

947

  1. CM
    Christopher M. Overall

    University of British Columbia, Canada

    8 publications · 829 citations

    8

    h-index

  2. JN
    Jayachandran N. Kizhakkedathu

    University of British Columbia, Canada

    3 publications · 396 citations

    3

    h-index

  3. BI
    Bogdan I. Florea

    Leiden University, Netherlands

    3 publications · 127 citations

    3

    h-index

  4. JW
    Jeffrey W. Smith

    Sanford Burnham Prebys Medical Discovery Institute, United States

    3 publications · 241 citations

    3

    h-index

  5. AM
    Alexey M. Eroshkin

    Sanford Burnham Prebys Medical Discovery Institute, United States

    3 publications · 294 citations

    3

    h-index

1–5 of 947

Institutions

343

  1. University of British Columbia

    Vancouver, Canada

    11 h-index

    26 publications

    3.4K citations

  2. University of California, San Francisco

    San Francisco, United States

    7 h-index

    28 publications

    1.2K citations

  3. Harvard University

    Cambridge, United States

    5 h-index

    20 publications

    1.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    6 publications

    260 citations

  5. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    4 h-index

    29 publications

    2.5K citations

  6. Brigham and Women's Hospital

    Boston, United States

    3 h-index

    7 publications

    325 citations

  7. University of Pittsburgh

    Pittsburgh, United States

    3 h-index

    3 publications

    64 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    22 publications

    1.1K citations

1–8 of 343

Venues

  1. Journal of Biological Chemistry

    JBC · 9 publications · 572 citations

    9

    h-index

  2. Journal of Molecular Biology

    JMB · 7 publications · 364 citations

    7

    h-index

  3. Methods in molecular biology

    Book series · 6 publications · 115 citations

    6

    h-index

  4. Journal of Proteome Research

    JPR · 5 publications · 232 citations

    5

    h-index

  5. Molecular & Cellular Proteomics

    MCP · 5 publications · 402 citations

    5

    h-index

1–5