Concepedia

Probe Potency

Probe Potency is a chemical probe attribute that denotes the measure of a probe's ability to bind to or modulate a target biomolecule with high affinity and effectiveness, typically quantified by inhibitory or dissociative constants such as IC50 or Kd values.

3

Publications

155

Citations

34

Authors

9

Institutions

Publications per year

2017–2026

0

Parents

Publications

3

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

P. G. Humphreys, Paul Bamborough, Chun‐wa Chung et al. · Journal of Medicinal Chemistry · 2016 · 100 citations · Full text

, , +14

Rational design of HIV-1 fluorescent hydrolysis probes considering phylogenetic variation and probe performance

Claudia Althaus, Sara Gianella, Philip Rieder et al. · Journal of Virological Methods · 2010 · 31 citations

, , +15

Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase

Christina J. Crump, Heather E. Murrey, T. Eric Ballard et al. · ACS Chemical Neuroscience · 2016 · 24 citations

, , +16

Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron Microscopy

Floris J. van Dalen, Thomas Bakkum, Tyrza van Leeuwen et al. · Frontiers in Chemistry · 2021 · 10 citations · Full text

, , +17

1–4 of 3

Authors

34

  1. PB
    Paul Bamborough

    GlaxoSmithKline (United Kingdom), United Kingdom

    1 publications · 100 citations

    1

    h-index

  2. LG
    Laurie Gordon

    GlaxoSmithKline (United Kingdom), United Kingdom

    1 publications · 100 citations

    1

    h-index

  3. SG
    Sara Gianella

    University of California San Diego, United States

    1 publications · 31 citations

    1

    h-index

  4. PD
    Peter D. Craggs

    GlaxoSmithKline (United Kingdom), United Kingdom

    1 publications · 100 citations

    1

    h-index

  5. DF
    David F. Tough

    Jenner Institute, United Kingdom

    1 publications · 100 citations

    1

    h-index

1–5 of 34

Institutions

9

  1. GlaxoSmithKline (Germany)

    Hamburg, Germany

    1 h-index

    7 publications

    700 citations

  2. Pfizer (United States)

    New York, United States

    1 h-index

    4 publications

    96 citations

  3. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    1 h-index

    12 publications

    1.2K citations

  4. ETH Zurich

    Zurich, Switzerland

    1 h-index

    1 publications

    31 citations

  5. University of Strathclyde

    Glasgow, United Kingdom

    1 h-index

    6 publications

    600 citations

  6. University Hospital of Zurich

    Zurich, Switzerland

    1 h-index

    10 publications

    310 citations

  7. GlaxoSmithKline (Netherlands)

    Zeist, Netherlands

    1 h-index

    12 publications

    1.2K citations

  8. Memorial Sloan Kettering Cancer Center

    New York, United States

    1 h-index

    4 publications

    96 citations

1–8 of 9

Venues

  1. ACS Chemical Neuroscience

    1 publications · 24 citations

    1

    h-index

  2. Journal of Medicinal Chemistry

    1 publications · 100 citations

    1

    h-index

  3. Journal of Virological Methods

    1 publications · 31 citations

    1

    h-index

  4. Frontiers in Chemistry

    1 publications · 10 citations

1–4