Laurie Gordon

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Natalie H. Theodoulou, Paul Bamborough, Andrew J. Bannister et al. · Journal of Medicinal Chemistry · 2015 · 229 citations · Full text

Chemical Biology, Chromatin, Molecular Characterization +14

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

Jonathan T. Seal, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 207 citations · Full text

Novel Series, Medicine, Chemical Biology +4

Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides

Paul Bamborough, Hawa Diallo, Jonathan D. Goodacre et al. · Journal of Medicinal Chemistry · 2011 · 176 citations · Full text

Combinatorial Chemistry, Drug Target, Bioorganic Chemistry +19

Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain

Robert P. Law, Stephen J. Atkinson, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2018 · 118 citations · Full text

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

P. G. Humphreys, Paul Bamborough, Chun‐wa Chung et al. · Journal of Medicinal Chemistry · 2016 · 97 citations · Full text

Molecular Regulation, Immunology, Immunotherapeutics +22