P. G. Humphreys

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Natalie H. Theodoulou, Paul Bamborough, Andrew J. Bannister et al. · Journal of Medicinal Chemistry · 2015 · 229 citations · Full text

Chemical Biology, Chromatin, Molecular Characterization +14

Total Synthesis of the Strychnos Alkaloid (+)-Minfiensine: Tandem Enantioselective Intramolecular Heck−Iminium Ion Cyclization

Amy B. Dounay, P. G. Humphreys, Larry E. Overman et al. · Journal of the American Chemical Society · 2008 · 211 citations · Full text

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

Zuni I. Bassi, Martin C. Fillmore, Afjal H. Miah et al. · ACS Chemical Biology · 2018 · 173 citations

Inflammation, P300/cbp-associated Factor, Molecular Immunology +15

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

P. G. Humphreys, Paul Bamborough, Chun‐wa Chung et al. · Journal of Medicinal Chemistry · 2016 · 97 citations · Full text

Molecular Regulation, Immunology, Immunotherapeutics +22

Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening

Christopher R. Wellaway, Dominique Amans, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2020 · 69 citations · Full text