Concepedia

Phosphatase-mediated Feedback

Phosphatase-Mediated Feedback is a regulatory mechanism in signal transduction pathways in which the activity of protein phosphatases selectively dephosphorylates signaling components to modulate pathway output, thereby providing negative or positive feedback that maintains signaling fidelity and homeostasis.

8

Publications

1.5K

Citations

47

Authors

28

Institutions

Publications per year

2017–2026

2

Parents

Publications

8

puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila

Enrique Martı́n-Blanco, Alexandra Gampel, Julia Ring et al. · Genes & Development · 1998 · 692 citations · Full text

, , +14

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

Keiichi Morita · The EMBO Journal · 2001 · 294 citations · Full text

, , +16

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

Nicola Aceto, Nina Sausgruber, Heike Brinkhaus et al. · Nature Medicine · 2012 · 267 citations

, , +17

CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation

Qixu Cai, Menglong Zeng, Xiandeng Wu et al. · Cell Research · 2020 · 79 citations · Full text

, , +14

Gain control of N‐methyl‐D‐aspartate receptor activity by receptor‐like protein tyrosine phosphatase α

The EMBO Journal · 2002 · 78 citations · Full text

, , +16

1–5 of 8

Authors

47

  1. XW
    Xiandeng Wu

    Hong Kong University of Science and Technology, Hong Kong SAR China

    1 publications · 79 citations

    1

    h-index

  2. JR
    Julia Ring

    University of Graz, Austria

    1 publications · 692 citations

    1

    h-index

  3. LC
    Luigi Carlessi

    Fondazione IRCCS Istituto Nazionale dei Tumori, Italy

    1 publications · 34 citations

    1

    h-index

  4. MS
    Michael Stadler

    Friedrich Miescher Institute, Switzerland

    1 publications · 267 citations

    1

    h-index

  5. NK
    Nikolai Kirov

    New York University, United States

    1 publications · 692 citations

    1

    h-index

1–5 of 47

Institutions

28

  1. IFOM

    Milan, Italy

    2 h-index

    4 publications

    868 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    1 h-index

    2 publications

    534 citations

  3. SIB Swiss Institute of Bioinformatics

    Lausanne, Switzerland

    1 h-index

    3 publications

    801 citations

  4. Novartis (Switzerland)

    Basel, Switzerland

    1 h-index

    1 publications

    267 citations

  5. Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Italy

    1 h-index

    4 publications

    136 citations

  6. Tokyo Medical and Dental University

    Tokyo, Japan

    1 h-index

    7 publications

    2.1K citations

  7. Southern University of Science and Technology

    Shenzhen, China

    1 h-index

    1 publications

    79 citations

  8. University College Dublin

    Dublin, Ireland

    1 h-index

    1 publications

    67 citations

1–8 of 28

Venues

  1. The EMBO Journal

    2 publications · 372 citations

    2

    h-index

  2. Cell Research

    1 publications · 79 citations

    1

    h-index

  3. FEBS Letters

    1 publications · 17 citations

    1

    h-index

  4. 1

    h-index

  5. Nature Medicine

    1 publications · 267 citations

    1

    h-index

1–5