Concepedia

Phenotypic Target Deconvolution

Phenotypic Target Deconvolution is a methodological approach in drug discovery that identifies the molecular target(s) underlying an observed phenotypic response by systematically linking bioactive compounds to their mechanisms of action through integrative experimental and computational analyses.

17

Publications

576

Citations

172

Authors

68

Institutions

Publications per year

2017–2026

11

Parents

Publications

17

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata et al. · Science Advances · 2019 · 136 citations · Full text

, , +14

Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells

Bruna Corominas-Faja, Elisabet Cuyàs, Jesús Lozano‐Sánchez et al. · Carcinogenesis · 2018 · 61 citations · Full text

, , +17

Building Predictive Models for Mechanism-of-Action Classification from Phenotypic Assay Data Sets

Ellen L. Berg, Jian Yang, Mark A. Polokoff · SLAS DISCOVERY · 2013 · 46 citations · Full text

, , +13

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

Stephan Eckert, Nicola Berner, Karl Kramer et al. · Nature Biotechnology · 2024 · 40 citations · Full text

, , +15

Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery

Fang Ye · Journal of Pharmacological and Toxicological Methods · 2013 · 38 citations

, , +10

1–5 of 17

Authors

172

  1. SL
    Severin Lechner

    Technical University of Munich, Germany

    2 publications · 70 citations

    2

    h-index

  2. BK
    Bernhard Küster

    Technical University of Munich, Germany

    2 publications · 70 citations

    2

    h-index

  3. LS
    Léonardo Scapozza

    University of Geneva, Switzerland

    1 publications · 18 citations

    1

    h-index

  4. AS
    Amirhossein Sakhteman

    Shiraz University of Medical Sciences, Iran

    1 publications · 40 citations

    1

    h-index

  5. YC
    Yun-Chien Chang

    Technical University of Munich, Germany

    1 publications · 30 citations

    1

    h-index

1–5 of 172

Institutions

68

  1. Technical University of Munich

    Munich, Germany

    2 h-index

    22 publications

    810 citations

  2. German Cancer Research Center

    Heidelberg, Germany

    2 h-index

    6 publications

    210 citations

  3. Heidelberg University

    Heidelberg, Germany

    2 h-index

    4 publications

    140 citations

  4. Institut de Recerca Biomèdica Catalunya Sud

    Tarragona, Spain

    1 h-index

    2 publications

    122 citations

  5. Otto-von-Guericke-Universität Magdeburg

    Magdeburg, Germany

    1 h-index

    2 publications

    24 citations

  6. Saitama Medical University

    Morohongō, Japan

    1 h-index

    2 publications

    272 citations

  7. Waseda University

    Tokyo, Japan

    1 h-index

    1 publications

    136 citations

  8. Instituto de Salud Carlos III

    Madrid, Spain

    1 h-index

    1 publications

    61 citations

1–8 of 68

Venues

  1. Nature Communications

    2 publications · 48 citations

    2

    h-index

  2. Journal of Medicinal Chemistry

    2 publications · 30 citations

    2

    h-index

  3. SLAS DISCOVERY

    2 publications · 65 citations

    2

    h-index

  4. Carcinogenesis

    1 publications · 61 citations

    1

    h-index

  5. Molecular Therapy

    1 publications · 14 citations

    1

    h-index

1–5