Target-based Repurposing

Target-Based Repurposing is a drug repurposing strategy that identifies new therapeutic indications for existing drugs by systematically exploiting their known or predicted interactions with specific molecular targets or biomarkers, typically via experimental or computational screening against disease-relevant proteins or pathways.

Publications

4.6K

Citations

428

Authors

166

Institutions

Publications per year

2017–2026

Parents

Drug Repurposing

Children

Druggable Target DiscoveryGenomic Target PrioritizationIon Channel TargetingLigand-based Target DiscoveryNetwork-based Target PrioritizationNuclear Receptor TargetingPathway-centric RepurposingPhenotypic Target DeconvolutionProteomic Target PrioritizationStructure-based Target Discovery

Publications

The druggable genome and support for target identification and validation in drug development

Chris Finan, Anna Gaulton, Felix Krüger et al. · Science Translational Medicine · 2017 · 1K citations

Pharmacy, Bioinformatics, Genetics +17

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease

Mahmoud Kandeel, Mohammed Al‐Nazawi · Life Sciences · 2020 · 429 citations · Full text

Pharmacy, Infectious Diseases, Medicinal Chemistry +11

In silico studies on therapeutic agents for COVID-19: Drug repurposing approach

Bhumi Shah, Palmi Modi, Sneha R. Sagar · Life Sciences · 2020 · 424 citations · Full text

Pharmacy, Infectious Diseases, Pharmacology +14

Drug Repurposing: Far Beyond New Targets for Old Drugs

Tudor I. Oprea, Jordi Mestres · The AAPS Journal · 2012 · 291 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

On the Integration of In Silico Drug Design Methods for Drug Repurposing

E. Vila, Luca Pinzi, Noé Sturm et al. · Frontiers in Pharmacology · 2017 · 235 citations · Full text

Pharmacy, Bioinformatics, Drug Design +12

1–5 of 65

Authors

428

RK
Ryan Kelley
University of California San Diego, United States
2 publications · 1.1K citations
2
h-index
AF
Arnica F Lal
Sam Higginbottom Institute of Agriculture, India
2 publications · 23 citations
2
h-index
LG
Luana Galver
Illumina (United States), United States
2 publications · 1.1K citations
2
h-index
JP
Juan P. Casas
University College London, United Kingdom
2 publications · 1.1K citations
2
h-index
JE
Jorgen Engmann
University College London, United Kingdom
2 publications · 1.1K citations
2
h-index

1–5 of 428

Institutions

166

1–8 of 166

Venues

Life Sciences
4 publications · 966 citations
4
h-index
Nature Communications
3 publications · 167 citations
3
h-index
Nature
3 publications · 161 citations
3
h-index
ChemRxiv
Repository · 2 publications · 23 citations
2
h-index
Briefings in Bioinformatics
2 publications · 72 citations
2
h-index

1–5