Concepedia

Pathway-centric Repurposing

Pathway-Centric Repurposing is a computational drug repurposing approach that identifies new therapeutic uses for existing compounds by analyzing their effects on disease-relevant biological pathways, distinguished from network- or target-based methods through its focus on pathway-level perturbations rather than individual targets or network topology.

6

Publications

264

Citations

61

Authors

28

Institutions

Publications per year

2017–2026

5

Parents

Publications

6

Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery

Hairi Li, Hongyan Zhou, Dong Wang et al. · Proceedings of the National Academy of Sciences · 2012 · 90 citations · Full text

, , +14

Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies

Namshik Han, Woochang Hwang, Konstantinos Tzelepis et al. · Science Advances · 2021 · 61 citations · Full text

, , +14

Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis

Giulia Fiscon, Federica Conte, Susanna Amadio et al. · Neurotherapeutics · 2021 · 48 citations · Full text

, , +16

Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing

Pandikannan Krishnamoorthy, Athira S. Raj, Swagnik Roy et al. · Computers in Biology and Medicine · 2020 · 36 citations · Full text

, , +16

Identifying patterns to uncover the importance of biological pathways on known drug repurposing scenarios

Belén Otero-Carrasco, Esther Ugarte Carro, Lucia Prieto Santamaría et al. · BMC Genomics · 2024 · 17 citations · Full text

, , +13

1–5 of 6

Authors

61

  1. HL
    Hairi Li

    University of California San Diego, United States

    1 publications · 90 citations

    1

    h-index

  2. SW
    Sabrina Weber

    Karlsruhe Institute of Technology, Germany

    1 publications · 12 citations

    1

    h-index

  3. JK
    Jana Ketzel

    Otto-von-Guericke-Universität Magdeburg, Germany

    1 publications · 12 citations

    1

    h-index

  4. SS
    Sonja Sievers

    Max Planck Institute of Molecular Physiology, Germany

    1 publications · 12 citations

    1

    h-index

  5. NH
    Namshik Han

    University of Cambridge, United Kingdom

    1 publications · 61 citations

    1

    h-index

1–5 of 61

Institutions

28

  1. Universidad Politécnica de Madrid

    Madrid, Spain

    1 h-index

    6 publications

    102 citations

  2. Otto-von-Guericke-Universität Magdeburg

    Magdeburg, Germany

    1 h-index

    2 publications

    24 citations

  3. Signosis (United States)

    Santa Clara, United States

    1 h-index

    1 publications

    90 citations

  4. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    1 h-index

    3 publications

    36 citations

  5. University of Cambridge

    Cambridge, United Kingdom

    1 h-index

    13 publications

    793 citations

  6. The Gurdon Institute

    Cambridge, United Kingdom

    1 h-index

    1 publications

    61 citations

  7. Justus-Liebig-Universität Gießen

    Giessen, Germany

    1 h-index

    3 publications

    183 citations

  8. Gruppo Italiano per lo Studio dei Carcinomi dell’Apparato Digerente

    Parabiago, Italy

    1 h-index

    1 publications

    48 citations

1–8 of 28

Venues

  1. BMC Genomics

    1 publications · 17 citations

    1

    h-index

  2. Science Advances

    1 publications · 61 citations

    1

    h-index

  3. Computers in Biology and Medicine

    1 publications · 36 citations

    1

    h-index

  4. Journal of Medicinal Chemistry

    1 publications · 12 citations

    1

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 90 citations

    1

    h-index

1–5