Concepedia

Pharmacodynamic Optimization

Pharmacodynamic Optimization is a pharmacological strategy that systematically enhances drug efficacy and safety by modulating the dynamic interactions between antimicrobial agents and their biological targets to achieve desired therapeutic outcomes.

100

Publications

3.8K

Citations

744

Authors

203

Institutions

Publications per year

2017–2026

38

Parents

Publications

100

Rivastigmine-loaded PLGA and PBCA nanoparticles: Preparation, optimization, characterization, in vitro and pharmacodynamic studies

Shrinidh Joshi, Sandip S. Chavhan, Krutika Sawant · European Journal of Pharmaceutics and Biopharmaceutics · 2010 · 232 citations

, , +16

Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae

Catharine C. Bulik, David P. Nicolau · Antimicrobial Agents and Chemotherapy · 2011 · 199 citations · Full text

, , +16

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 <i>H</i> -pyrrolo[2,3- <i>d</i> ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

Jaclyn L. Henderson, Bethany L. Kormos, Matthew M. Hayward et al. · Journal of Medicinal Chemistry · 2014 · 182 citations · Full text

, , +14

Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets

Kartik Sehgal, Rituparna Das, Lin Zhang et al. · Blood · 2015 · 132 citations · Full text

, , +16

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

Mathieu Pizzonero, Sonia Dupont, Marielle Babel et al. · Journal of Medicinal Chemistry · 2014 · 110 citations · Full text

, , +17

1–5 of 100

Authors

744

  1. DP
    David P. Nicolau

    Hartford Hospital, United States

    11 publications · 554 citations

    10

    h-index

  2. JL
    Joseph L. Kuti

    Hartford Hospital, United States

    7 publications · 297 citations

    7

    h-index

  3. FP
    Federico Pea

    University of Udine, Italy

    5 publications · 207 citations

    6

    h-index

  4. JB
    Jürgen B. Bulitta

    Monash University, Australia

    5 publications · 137 citations

    5

    h-index

  5. BT
    Brian T. Tsuji

    University at Buffalo, State University of New York, United States

    4 publications · 94 citations

    4

    h-index

1–5 of 744

Institutions

203

  1. Hartford Hospital

    Hartford, United States

    12 h-index

    26 publications

    1.2K citations

  2. University of Florida

    Gainesville, United States

    7 h-index

    34 publications

    662 citations

  3. University at Buffalo, State University of New York

    Buffalo, United States

    5 h-index

    21 publications

    543 citations

  4. Monash University

    Melbourne, Australia

    4 h-index

    8 publications

    256 citations

  5. Hartford Financial Services (United States)

    Hartford, United States

    4 h-index

    7 publications

    556 citations

  6. Pfizer (United States)

    New York, United States

    3 h-index

    17 publications

    2.9K citations

  7. University of Bologna

    Bologna, Italy

    3 h-index

    13 publications

    452 citations

  8. Florida College

    Temple Terrace, United States

    3 h-index

    22 publications

    430 citations

1–8 of 203

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 9 publications · 615 citations

    10

    h-index

  2. Journal of Medicinal Chemistry

    7 publications · 426 citations

    7

    h-index

  3. PubMed

    Repository · 5 publications · 176 citations

    5

    h-index

  4. Journal of Antimicrobial Chemotherapy

    JAC · 5 publications · 240 citations

    5

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    4 publications · 107 citations

    4

    h-index

1–5