Concepedia

One-carbon Pathways

One-Carbon Pathways is a biochemical framework that orchestrates the transfer and metabolism of one-carbon units, primarily through folate-mediated reactions, to support nucleotide synthesis, methylation processes, and redox homeostasis within cellular metabolism.

245

Publications

18.1K

Citations

1.6K

Authors

522

Institutions

Publications per year

2017–2026

85

Parents

Publications

245

Using carbon dioxide as a building block in organic synthesis

Qiang Liu, Lipeng Wu, Ralf Jackstell et al. · Nature Communications · 2015 · 2.1K citations · Full text

, , +16

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

Samantha J. Mentch, Mahya Mehrmohamadi, Lei Huang et al. · Cell Metabolism · 2015 · 683 citations · Full text

, , +15

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan et al. · Nature Chemical Biology · 2016 · 589 citations · Full text

, , +14

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

Dannielle C. DeWaal, Véronique Nogueira, Alexander R. Terry et al. · Nature Communications · 2018 · 558 citations · Full text

, , +17

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Xiaoyan Bao, Shao‐En Ong, Olga Goldberger et al. · eLife · 2016 · 454 citations · Full text

, , +17

1–5 of 245

Authors

1.6K

  1. CM
    Cornelia M. Ulrich

    Fred Hutch Cancer Center, United States

    7 publications · 520 citations

    7

    h-index

  2. PJ
    Patrick J. Stover

    Cornell University, United States

    7 publications · 853 citations

    7

    h-index

  3. MS
    Martha S. Field

    Cornell University, United States

    5 publications · 193 citations

    5

    h-index

  4. CH
    Cheng‐Han Hsieh

    National Chung Cheng University, Taiwan

    4 publications · 135 citations

    4

    h-index

  5. JF
    Jesse F. Gregory

    University of Florida, United States

    4 publications · 356 citations

    4

    h-index

1–5 of 1.6K

Institutions

522

  1. Cornell University

    Ithaca, United States

    13 h-index

    46 publications

    9.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    20 publications

    958 citations

  3. National Institutes of Health

    Bethesda, United States

    9 h-index

    47 publications

    8K citations

  4. National Cancer Institute

    Bethesda, United States

    9 h-index

    44 publications

    2K citations

  5. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    70 publications

    9.3K citations

  6. University of Florida

    Gainesville, United States

    8 h-index

    14 publications

    1.7K citations

  7. Harvard University

    Cambridge, United States

    8 h-index

    41 publications

    8.6K citations

  8. Fred Hutch Cancer Center

    Seattle, United States

    7 h-index

    63 publications

    2.6K citations

1–8 of 522

Venues

  1. Journal of Bacteriology

    JB · 10 publications · 532 citations

    10

    h-index

  2. Scientific Reports

    9 publications · 319 citations

    9

    h-index

  3. Tetrahedron

    8 publications · 320 citations

    8

    h-index

  4. American Journal of Clinical Nutrition

    AJCN · 7 publications · 375 citations

    7

    h-index

  5. Journal of Nutrition

    JN · 7 publications · 692 citations

    7

    h-index

1–5