Concepedia

Oncogene Cooperation

Oncogene Cooperation is a molecular oncology phenomenon in which two or more distinct oncogenes interact synergistically within a single cell to drive tumorigenesis more effectively than either oncogene alone, typically by coordinately deregulating complementary signaling pathways involved in cell proliferation, survival, or transformation.

234

Publications

24.8K

Citations

1.7K

Authors

490

Institutions

Publications per year

2017–2026

39

Parents

Children

Publications

234

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land, Luis F. Parada, Robert A. Weinberg · Nature · 1983 · 2.9K citations

, , +16

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

Jacqueline J.L. Jacobs, Blanca Scheijen, Jan Willem Voncken et al. · Genes & Development · 1999 · 1.1K citations · Full text

, , +17

Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

Ari Melnick, Jonathan D. Licht · Blood · 1999 · 1K citations

, , +12

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

Tod Smeal, Bernard Binétruy, Daniel A. Mercola et al. · Nature · 1991 · 800 citations

, , +14

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

Maarten van Lohuizen, Sjef Verbeek, Blanca Scheljen et al. · Cell · 1991 · 771 citations

, , +14

1–5 of 234

Authors

1.7K

  1. HL
    Hartmut Land

    The Honourable Society of Lincoln's Inn, United Kingdom

    5 publications · 3.4K citations

    5

    h-index

  2. GS
    Guy Sauvageau

    Université de Montréal, Canada

    4 publications · 151 citations

    4

    h-index

  3. HE
    Helena E. Richardson

    Peter MacCallum Cancer Centre, Australia

    4 publications · 150 citations

    4

    h-index

  4. GI
    Gérard I. Evan

    University of California, San Francisco, United States

    3 publications · 1.4K citations

    3

    h-index

  5. AB
    Allan Bradley

    Baylor College of Medicine, United States

    3 publications · 380 citations

    3

    h-index

1–5 of 1.7K

Institutions

490

  1. University of California San Diego

    San Diego, United States

    11 h-index

    49 publications

    9.3K citations

  2. University of California, San Francisco

    San Francisco, United States

    10 h-index

    34 publications

    5.3K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    21 publications

    2.7K citations

  4. Harvard University

    Cambridge, United States

    8 h-index

    21 publications

    2.2K citations

  5. Memorial Sloan Kettering Cancer Center

    New York, United States

    8 h-index

    42 publications

    7.4K citations

  6. National Cancer Institute

    Bethesda, United States

    7 h-index

    15 publications

    1.8K citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    6 h-index

    16 publications

    591 citations

  8. The Netherlands Cancer Institute

    Amsterdam, The Netherlands

    6 h-index

    31 publications

    12.3K citations

1–8 of 490

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 22 publications · 2.5K citations

    20

    h-index

  2. Oncogene

    16 publications · 1K citations

    16

    h-index

  3. PubMed

    Repository · 20 publications · 1K citations

    14

    h-index

  4. Molecular and Cellular Biology

    MCB · 12 publications · 982 citations

    11

    h-index

  5. Cancer Research

    9 publications · 781 citations

    9

    h-index

1–5