Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Masahiko Hibi, Anning Lin, Tod Smeal, +2

Genes & Development

Molecular RegulationMolecular BiologySerines 63Cellular PhysiologyUv Light +16

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

Hsin‐Fang Yang‐Yen, Jean‐Claude Chambard, Yu-Lin Sun, +4

Cell

Transcriptional RegulationSignal TransductionG Protein-coupled ReceptorGeneticsReceptor (Biochemistry) +7

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

Robert Chiu, William J. Boyle, Jennifer Meek, +3

Cell

Transcriptional RegulationSystems BiologySignal TransductionSignaling PathwayCell Regulation +10

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

Peter Angel, Kazue Hattori, Tod Smeal, +1

Cell

Molecular ResearchNatural SciencesGeneticsBiochemical GeneticsMolecular Biology +7

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

William J. Boyle, Tod Smeal, Libert H.K. Defize, +4

Cell

ChromatinSignal TransductionProtein Kinase CCell RegulationNatural Sciences +9

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

Yoram Devary, Roberta A. Gottlieb, Tod Smeal, +1

Cell

Signal TransductionSrc Tyrosine KinasesCell RegulationReceptor Tyrosine KinasePhotocarcinogenesis +5

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

Tod Smeal, Bernard Binétruy, Daniel A. Mercola, +2

Nature

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationMedicine +9

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

Jonathan Arias, Arthur S. Alberts, Paul K. Brindle, +5

Nature

Transcriptional RegulationCell DivisionMolecular RegulationGeneticsGene Expression +8

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

Bernard Binétruy, Tod Smeal, Michael Karin

Nature

Activation DomainSignal TransductionCell RegulationSignaling PathwayMolecular Regulation +8

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Ted W. Johnson, Paul Richardson, Simon Bailey, +30

Journal of Medicinal Chemistry