Concepedia

Off-target Tissue Effects

Off-Target Tissue Effects is a biological phenomenon characterized by the unintended interaction or impact of a therapeutic agent, intervention, or regulatory process on non-intended tissues, distinct from the target tissue of interest, thereby potentially eliciting adverse or confounding physiological responses.

125

Publications

7.2K

Citations

994

Authors

359

Institutions

Publications per year

2017–2026

82

Parents

Publications

125

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Zachary E. Stine, Jinsong Xia, Yunqi Lu et al. · Journal of Clinical Investigation · 2015 · 397 citations · Full text

, , +14

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle et al. · Nature Communications · 2017 · 351 citations · Full text

, , +11

Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Martin M. Jendryka, Monika Palchaudhuri, Daniel Ursu et al. · Scientific Reports · 2019 · 323 citations · Full text

, , +15

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays

Meghana Kulkarni, Matthew A. Booker, Serena J. Silver et al. · Nature Methods · 2006 · 300 citations

, , +15

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Prasanta K. Dash, Rafal Kaminski, Ramona Bella et al. · Nature Communications · 2019 · 296 citations · Full text

, , +16

1–5 of 125

Authors

994

  1. TD
    Thomas D. Arnold

    University of California, San Francisco, United States

    2 publications · 63 citations

    2

    h-index

  2. RG
    Reinhold G. Erben

    University of Veterinary Medicine Vienna, Austria

    2 publications · 134 citations

    2

    h-index

  3. CC
    Chen Chen

    Agriculture and Agri-Food Canada, Canada

    2 publications · 333 citations

    2

    h-index

  4. MD
    Martina Donadoni

    Temple University, United States

    2 publications · 333 citations

    2

    h-index

  5. TH
    Tricia H. Burdo

    Boston College, United States

    2 publications · 333 citations

    2

    h-index

1–5 of 994

Institutions

359

  1. Harvard University

    Cambridge, United States

    5 h-index

    17 publications

    2.1K citations

  2. Stanford University

    Stanford, United States

    5 h-index

    40 publications

    3.2K citations

  3. Monash University

    Melbourne, Australia

    5 h-index

    17 publications

    709 citations

  4. University of California, San Francisco

    San Francisco, United States

    4 h-index

    18 publications

    395 citations

  5. University of Oxford

    Oxford, United Kingdom

    3 h-index

    4 publications

    191 citations

  6. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    22 publications

    2.5K citations

  7. Leiden University

    Leiden, The Netherlands

    3 h-index

    30 publications

    4.7K citations

  8. The University of Melbourne

    Melbourne, Australia

    3 h-index

    8 publications

    277 citations

1–8 of 359

Venues

  1. Scientific Reports

    9 publications · 640 citations

    9

    h-index

  2. PLoS ONE

    5 publications · 245 citations

    4

    h-index

  3. Angewandte Chemie International Edition

    3 publications · 151 citations

    3

    h-index

  4. Advanced Materials

    3 publications · 404 citations

    3

    h-index

  5. ACS Nano

    3 publications · 499 citations

    3

    h-index

1–5