Concepedia

Off-target Integration

Off-Target Integration is a genomic event in which a genetic construct is inserted into a non-intended locus within the genome, differing from on-target integration by its unintended location and potential to disrupt native gene function or regulatory elements.

13

Publications

1.3K

Citations

87

Authors

38

Institutions

Publications per year

2017–2026

9

Variants

Off-target Insertion

Parents

Publications

13

Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9

Yuxuan Wu, Dan Liang, Yinghua Wang et al. · Cell stem cell · 2013 · 612 citations · Full text

, , +11

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

Alex N. Zelensky, Joost Schimmel, Hanneke Kool et al. · Nature Communications · 2017 · 127 citations · Full text

, , +17

Cloning of the LYS5 gene encoding saccharopine dehydrogenase from the yeast Yarrowia lipolytica by target integration

Jian‐Wu Xuan, Philippe Fournier, Claude Gaillardin · Current Genetics · 1988 · 125 citations

, , +8

Aspirin and coronary heart disease: findings of a prospective study.

Edward Hammond, Lawrence Garfinkel · BMJ · 1975 · 83 citations · Full text

, , +15

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

Isaac P. Witte, George D. Lampe, Simon Eitzinger et al. · Science · 2025 · 78 citations · Full text

, , +14

1–5 of 13

Authors

87

  1. EM
    Esther Mintzer

    University of Massachusetts Chan Medical School, United States

    2 publications · 69 citations

    2

    h-index

  2. KL
    Kevin Luk

    University of Massachusetts Chan Medical School, United States

    2 publications · 69 citations

    2

    h-index

  3. JS
    Josias Soares de Brito

    University of Massachusetts Chan Medical School, United States

    2 publications · 69 citations

    2

    h-index

  4. JV
    Joel Vega‐Badillo

    Universidad Nacional Autónoma de México, Mexico

    2 publications · 69 citations

    2

    h-index

  5. EJ
    Erik J. Sontheimer

    University of Massachusetts Chan Medical School, United States

    2 publications · 69 citations

    2

    h-index

1–5 of 87

Institutions

38

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    14 publications

    975 citations

  2. University of Massachusetts Chan Medical School

    Worcester, United States

    2 h-index

    25 publications

    804 citations

  3. Erasmus University Rotterdam

    Rotterdam, The Netherlands

    1 h-index

    1 publications

    127 citations

  4. Rutgers, The State University of New Jersey

    New Brunswick, United States

    1 h-index

    6 publications

    228 citations

  5. ShanghaiTech University

    Shanghai, China

    1 h-index

    2 publications

    1.2K citations

  6. Erasmus MC Cancer Institute

    Rotterdam, The Netherlands

    1 h-index

    1 publications

    127 citations

  7. National Center for Biotechnology Information

    Bethesda, United States

    1 h-index

    5 publications

    190 citations

  8. Duke Medical Center

    Durham, United States

    1 h-index

    2 publications

    58 citations

1–8 of 38

Venues

  1. The CRISPR Journal

    2 publications · 92 citations

    3

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 83 citations

    2

    h-index

  3. Science

    1 publications · 78 citations

    1

    h-index

  4. Cell stem cell

    1 publications · 612 citations

    1

    h-index

  5. BMJ

    1 publications · 83 citations

    1

    h-index

1–5