Concepedia

Off-target Expression

Off-Target Expression is a biological phenomenon in the context of tissue targeting wherein a therapeutic agent or genetic construct is expressed or active in non-intended tissues or cells, diverging from its designated site of action.

59

Publications

3.6K

Citations

483

Authors

208

Institutions

Publications per year

2017–2026

36

Parents

Publications

59

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Manuel Carrasco, Suman Alishetty, Mohamad‐Gabriel Alameh et al. · Communications Biology · 2021 · 408 citations · Full text

, , +17

A computational study of off-target effects of RNA interference

Shibin Qiu · Nucleic Acids Research · 2005 · 273 citations · Full text

, , +15

Computational Estimation and Experimental Verification of Off-Target Silencing during Posttranscriptional Gene Silencing in Plants

Ping Xu, Yuanji Zhang, Li Kang et al. · PLANT PHYSIOLOGY · 2006 · 217 citations · Full text

, , +16

A novel rapamycin analog is highly selective for mTORC1 in vivo

Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu et al. · Nature Communications · 2019 · 199 citations · Full text

, , +14

Unsupervised removal of systematic background noise from droplet-based single-cell experiments using <tt>CellBender</tt>

Stephen J. Fleming, Mark Chaffin, Alessandro Arduini et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 193 citations · Full text

, , +17

1–5 of 59

Authors

483

  1. PS
    Pål Sætrom

    Norwegian University of Science and Technology, Norway

    2 publications · 102 citations

    2

    h-index

  2. WL
    Wei Li

    Northeast Agricultural University, China

    1 publications · 28 citations

    1

    h-index

  3. JP
    James Pickel

    National Institutes of Health, United States

    1 publications · 15 citations

    1

    h-index

  4. HH
    Harald Hartweger

    Rockefeller University, United States

    1 publications · 30 citations

    1

    h-index

  5. SK
    Shlomit Kfir‐Erenfeld

    Hadassah Medical Center, Israel

    1 publications · 19 citations

    1

    h-index

1–5 of 483

Institutions

208

  1. Heidelberg University

    Heidelberg, Germany

    4 h-index

    16 publications

    394 citations

  2. German Cancer Research Center

    Heidelberg, Germany

    3 h-index

    6 publications

    284 citations

  3. Inserm

    Paris, France

    2 h-index

    18 publications

    1.3K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    3 publications

    158 citations

  5. Technische Universität Dresden

    Dresden, Germany

    2 h-index

    9 publications

    163 citations

  6. University of California San Diego

    San Diego, United States

    2 h-index

    10 publications

    248 citations

  7. Technical University of Munich

    Munich, Germany

    2 h-index

    22 publications

    2.2K citations

  8. Université Paris Cité

    Paris, France

    2 h-index

    3 publications

    158 citations

1–8 of 208

Venues

  1. Nature Communications

    6 publications · 462 citations

    6

    h-index

  2. PLoS ONE

    5 publications · 112 citations

    5

    h-index

  3. Nucleic Acids Research

    4 publications · 334 citations

    4

    h-index

  4. Molecular Therapy

    3 publications · 216 citations

    3

    h-index

  5. RNA

    2 publications · 103 citations

    2

    h-index

1–5