Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance

Mari Carmen Gómez‐Cabrera, Elena B. Domènech, Marco Romagnoli, +5

American Journal of Clinical Nutrition

Sport PhysiologyMuscle FunctionKinesiologyPhysical FitnessExercise +10

Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender

Stephen J. Fleming, Mark Chaffin, Alessandro Arduini, +6

Nature Methods

EngineeringMicroscopyMedicineBioimage AnalysisNoise +9

Transcriptional and Cellular Diversity of the Human Heart

Nathan R. Tucker, Mark Chaffin, Stephen J. Fleming, +15

Circulation

Preterm Resuscitation With Low Oxygen Causes Less Oxidative Stress, Inflammation, and Chronic Lung Disease

Máximo Vento, Manuel Moro, Raquel Escrig, +8

PEDIATRICS

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

Mark Chaffin, Irinna Papangeli, Bridget Simonson, +16

Nature

Cardiac MuscleCardiomyopathyHeart FailureCardiovascular DiseasePhysiology +4

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production

Alban Longchamp, Teodelinda Mirabella, Alessandro Arduini, +21

Cell

AngiogenesisDevelopmental BiologyNatural SciencesEndothelial DysfunctionVascular Biology +7

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

Scott B. Widenmaier, Nicole Snyder, Truc Nguyen, +6

Cell

Molecular PhysiologySignal TransductionBiochemistryOxysterolAtherosclerosis +7

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

Ling Yang, Ediz S. Calay, Jason Fan, +6

Science

Deep learning enables genetic analysis of the human thoracic aorta

James P. Pirruccello, Mark Chaffin, Elizabeth L. Chou, +27

Nature Genetics

Systems BiologyEngineeringMachine LearningGeneticsBiomedical Data Science +6

Unsupervised removal of systematic background noise from droplet-based single-cell experiments using <tt>CellBender</tt>

Stephen J. Fleming, Mark Chaffin, Alessandro Arduini, +6

EngineeringMicroscopyTranscriptomics TechnologyGene Expression ProfilingTrajectory Analysis +19