Concepedia

Non-specific Binding Reduction

Non-Specific Binding Reduction is a methodological strategy in immunomagnetic separation that minimizes the adhesion of non-target entities to magnetic beads or target analytes by optimizing surface chemistry, blocking agents, or buffer conditions to enhance assay specificity.

151

Publications

6.1K

Citations

746

Authors

299

Institutions

Publications per year

2017–2026

28

Parents

Publications

151

Suppression of non-specific binding in serological Luminex assays

Tim Waterboer, Peter Sehr, Michael Pawlita · Journal of Immunological Methods · 2005 · 284 citations

, , +8

Immunomagnetic separation as a sensitive method for isolating<i>Escherichia coli</i>O157 from food samples

Dominic Wright, P. A. Chapman, C. A. Siddons · Epidemiology and Infection · 1994 · 191 citations · Full text

, , +16

Loss of brain 5-HT<sub>2</sub>receptors in Alzheimer's disease

J. Blin, Jean‐Claude Baron, Bruno Dubois et al. · Brain · 1993 · 172 citations

, , +16

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Emily K. Makowski, Patrick C. Kinnunen, Jie Huang et al. · Nature Communications · 2022 · 157 citations · Full text

, , +17

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Amita Datta‐Mannan, Arunkumar Thangaraju, Donmienne Leung et al. · mAbs · 2015 · 146 citations · Full text

, , +17

1–5 of 151

Authors

746

  1. HL
    Hervé Leh

    Centre National de la Recherche Scientifique, France

    2 publications · 48 citations

    2

    h-index

  2. TM
    Tiziana Mennini

    Mario Negri Institute for Pharmacological Research, Italy

    2 publications · 37 citations

    2

    h-index

  3. SD
    Stephen Daniels

    Dublin City University, Ireland

    2 publications · 47 citations

    2

    h-index

  4. MF
    M. Fiori

    Fidia Farmaceutici (Italy), Italy

    2 publications · 37 citations

    2

    h-index

  5. GF
    Graeme F. Woodworth

    University of Maryland, Baltimore, United States

    2 publications · 141 citations

    2

    h-index

1–5 of 746

Institutions

299

  1. Cornell University

    Ithaca, United States

    6 h-index

    24 publications

    1.5K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    20 publications

    492 citations

  3. University of California San Diego

    San Diego, United States

    3 h-index

    7 publications

    527 citations

  4. Johns Hopkins Medicine

    Baltimore, United States

    3 h-index

    10 publications

    443 citations

  5. Johns Hopkins University

    Baltimore, United States

    3 h-index

    10 publications

    443 citations

  6. Inserm

    Paris, France

    3 h-index

    8 publications

    1.1K citations

  7. University of Bristol

    Bristol, United Kingdom

    2 h-index

    10 publications

    188 citations

  8. University of Turku

    Turku, Finland

    2 h-index

    14 publications

    310 citations

1–8 of 299

Venues

  1. Journal of Immunological Methods

    8 publications · 506 citations

    8

    h-index

  2. Nucleic Acids Research

    6 publications · 288 citations

    6

    h-index

  3. PubMed

    Repository · 5 publications · 188 citations

    5

    h-index

  4. Scientific Reports

    4 publications · 66 citations

    4

    h-index

  5. PLoS ONE

    4 publications · 143 citations

    4

    h-index

1–5