Emily K. Makowski

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Emily K. Makowski, Patrick C. Kinnunen, Jie Huang et al. · Nature Communications · 2022 · 157 citations · Full text

Pharmacy, Biotechnology, Pharmacology +17

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Chang‐Han Lee, Tae Hyun Kang, Ophélie Godon et al. · Nature Communications · 2019 · 94 citations · Full text

Pharmacy, Immunology, Pharmacokinetics +17

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

Jennifer M. Zupancic, Alec A. Desai, John S. Schardt et al. · Cell chemical biology · 2021 · 58 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +9

Highly sensitive detection of antibody nonspecific interactions using flow cytometry

Emily K. Makowski, Lina Wu, Alec A. Desai et al. · mAbs · 2021 · 45 citations · Full text

Pharmacy, Biotechnology, Immunology +17

Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning

Emily K. Makowski, Tiexin Wang, Jennifer M. Zupancic et al. · Nature Biomedical Engineering · 2023 · 45 citations · Full text

Pharmacy, Biotechnology, Immunology +17