Alec A. Desai

Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility

Lilia A. Rabia, Alec A. Desai, Harkamal S. Jhajj et al. · Biochemical Engineering Journal · 2018 · 160 citations · Full text

Pharmacy, Biochemistry, Immunology +12

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Emily K. Makowski, Patrick C. Kinnunen, Jie Huang et al. · Nature Communications · 2022 · 157 citations · Full text

Pharmacy, Biotechnology, Pharmacology +17

Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96).

P Satishchandra, A Nalini, M. Gourie‐Devi et al. · PubMed · 2000 · 145 citations

Medicine, Infectious Diseases, Neurology +15

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

Jennifer M. Zupancic, Alec A. Desai, John S. Schardt et al. · Cell chemical biology · 2021 · 58 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +9

Physicochemical Rules for Identifying Monoclonal Antibodies with Drug-like Specificity

Yulei Zhang, Lina Wu, Priyanka Gupta et al. · Molecular Pharmaceutics · 2020 · 48 citations · Full text

Pharmacy, Immunology, Medicinal Chemistry +17