John S. Schardt

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

Tek N. Lamichhane, Anjana Jeyaram, Divya Patel et al. · Cellular and Molecular Bioengineering · 2016 · 365 citations · Full text

Extracellular Vesicles, Natural Sciences, Active Loading +9

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Emily K. Makowski, Patrick C. Kinnunen, Jie Huang et al. · Nature Communications · 2022 · 146 citations · Full text

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

Jennifer M. Zupancic, Alec A. Desai, John S. Schardt et al. · Cell chemical biology · 2021 · 52 citations · Full text

Chemical Engineering, Engineering, Nanotechnology +5

Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS‐CoV‐2 Variants

Jennifer M. Zupancic, John S. Schardt, Alec A. Desai et al. · Advanced Therapeutics · 2021 · 42 citations · Full text

Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning

Emily K. Makowski, Tiexin Wang, Jennifer M. Zupancic et al. · Nature Biomedical Engineering · 2023 · 39 citations · Full text

Interpretable Machine Learning, Systems Biology, Engineering +9