Concepedia

Neutralizing Antibody Evolution

Neutralizing Antibody Evolution is a theoretical framework within the study of affinity maturation that characterizes the sequential selection and optimization of B-cell receptors for enhanced binding specificity and neutralizing capacity against pathogenic epitopes through somatic hypermutation and clonal selection.

203

Publications

20.1K

Citations

2.1K

Authors

448

Institutions

Publications per year

2017–2026

152

Parents

Publications

203

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Xueling Wu, Zhi-Yong Yang, Yuxing Li et al. · Science · 2010 · 1.8K citations

, , +17

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

Douglas D. Richman, Terri Wrin, Susan J. Little et al. · Proceedings of the National Academy of Sciences · 2003 · 1.2K citations · Full text

, , +16

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Johannes F. Scheid, Hugo Mouquet, Beatrix Ueberheide et al. · Science · 2011 · 1.2K citations · Full text

, , +14

HIV vaccine design and the neutralizing antibody problem

Dennis R. Burton, Ronald C. Desrosiers, Robert W. Doms et al. · Nature Immunology · 2004 · 765 citations

, , +14

Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum

Aekkachai Tuekprakhon, Rungtiwa Nutalai, Aiste Dijokaite-Guraliuc et al. · Cell · 2022 · 762 citations · Full text

, , +13

1–5 of 203

Authors

2.1K

  1. MC
    Michel C. Nussenzweig

    Rockefeller University, United States

    13 publications · 2.6K citations

    12

    h-index

  2. DD
    David D. Ho

    Aaron Diamond AIDS Research Center, United States

    12 publications · 1.6K citations

    12

    h-index

  3. PD
    Peter D. Kwong

    National Institutes of Health, United States

    12 publications · 3.3K citations

    12

    h-index

  4. QW
    Qian Wang

    Columbia University, United States

    10 publications · 400 citations

    10

    h-index

  5. JR
    John R. Mascola

    National Institute of Allergy and Infectious Diseases, United States

    10 publications · 2.5K citations

    10

    h-index

1–5 of 2.1K

Institutions

448

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    21 h-index

    48 publications

    10.7K citations

  2. University of Washington

    Seattle, United States

    19 h-index

    47 publications

    10.1K citations

  3. Scripps Research Institute

    San Diego, United States

    17 h-index

    120 publications

    12.4K citations

  4. National Institutes of Health

    Bethesda, United States

    16 h-index

    187 publications

    55.6K citations

  5. Columbia University

    New York, United States

    16 h-index

    134 publications

    6.2K citations

  6. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    15 h-index

    181 publications

    52.9K citations

  7. Harvard University

    Cambridge, United States

    15 h-index

    66 publications

    10.1K citations

  8. Ragon Institute of MGH, MIT and Harvard

    Cambridge, United States

    15 h-index

    51 publications

    5.5K citations

1–8 of 448

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 39 publications · 2.2K citations

    22

    h-index

  2. Nature Communications

    19 publications · 1.7K citations

    18

    h-index

  3. Journal of Virology

    JVI · 13 publications · 859 citations

    13

    h-index

  4. Cell Reports

    10 publications · 406 citations

    10

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 1.9K citations

    7

    h-index

1–5