Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Xueling Wu, Zhi-Yong Yang, Yuxing Li, +21

Science

Broad Hiv-1 NeutralizationEngineeringRational DesignMedicineHuman Retrovirus +12

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Johannes F. Scheid, Hugo Mouquet, Niklas Feldhahn, +19

Nature

Hiv-infected IndividualsHuman RetrovirusHumoral ResponseImmunologyAntiviral Response +7

Proof of principle for epitope-focused vaccine design

Bruno E. Correia, John T. Bates, Rebecca J. Loomis, +24

Nature

VaccinationEpitope-focused Vaccine DesignCross-protectionVaccine TargetImmunology +4

Broad HIV-1 neutralization mediated by CD4-binding site antibodies

Yuxing Li, Stephen A. Migueles, Brent Welcher, +8

Nature Medicine

Broad Hiv-1 NeutralizationHuman RetrovirusImmunologyAntiviral ResponseVirology +4

Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals

Yuxing Li, Krisha Svehla, Mark K. Louder, +11

Journal of Virology

ImmunologyMolecular BiologyViral Structural ProteinViral NeutralizationVirus Structure +17

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

Yuxing Li, Sijy O’Dell, Laura M. Walker, +12

Journal of Virology

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Fabian Sesterhenn, Che Yang, Jaume Bonet, +29

Science

Rsv-neutralizing AntibodiesImmunologyMolecular BiologyImmunotherapySynthetic Immunology +17

HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

Rebecca M. Lynch, Patrick Wong, Lillian Tran, +5

Journal of Virology

Glycosylation, Hypogammaglobulinemia, and Resistance to Viral Infections

Mohammed Sadat, Susan Moir, Tae‐Wook Chun, +37

New England Journal of Medicine

HistocompatibilityImmunodeficienciesImmunologyGlycobiologyPathology +18

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Xuelian Zhao, Katie A. Howell, Shihua He, +25

Cell

VaccinationVaccine TargetViral PathogenesisImmunologyVirology +2