Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Xueling Wu, Zhi-Yong Yang, Yuxing Li, +21

Science

Broad Hiv-1 NeutralizationEngineeringRational DesignMedicineHuman Retrovirus +12

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Tongqing Zhou, Ivelin S. Georgiev, Xueling Wu, +15

Science

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Jason S. McLellan, Marie Pancera, Chris Carrico, +44

Nature

Virus StructureHuman RetrovirusImmunologyAntiviral ResponseMolecular Biology +7

A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice

Zhi-Yong Yang, Wing-Pui Kong, Yue Huang, +4

Nature

Development of a preventive vaccine for Ebola virus infection in primates

Nancy J. Sullivan, Anthony Sanchez, Pierre E. Rollin, +2

Nature

VaccinationMucosal VaccinationVaccine DevelopmentVaccine TargetImmunology +5

pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGN

Zhi-Yong Yang, Yue Huang, Ganesh Lakshmanan, +5

Journal of Virology

Virus StructureViral ReplicationPh-dependent EntryDendritic Cell TransferReporter Virus +13

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

Nicole L. Yates, Hua-Xin Liao, Youyi Fong, +28

Science Translational Medicine

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

Sung‐Youl Ko, Amarendra Pegu, Rebecca S. Rudicell, +18

Nature

Maternal ImmunizationVeterinary VaccinePathogenesisImmunologyTherapeutic Efficacy +3

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

Hua-Xin Liao, Mattia Bonsignori, S. Munir Alam, +39

Immunity

VaccinationVaccine DevelopmentVaccine InductionMedicineVaccine Target +9

Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys

Norman L. Letvin, John R. Mascola, Yue Sun, +11

Science

Vaccinated Siv-challenged MonkeysImmunologyCd4 T Cell ResponsesImmunotherapySimian Immunodeficiency Virus +18