Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Jason S. McLellan, Marie Pancera, Chris Carrico, +44

Nature

Virus StructureHuman RetrovirusImmunologyAntiviral ResponseMolecular Biology +7

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

Matthew J. Rardin, Wenjuan He, Yuya Nishida, +21

Cell Metabolism

Mitochondrial FunctionMitochondrial DynamicAutophagyMolecular BiologyMitochondrial Lysine Succinylome +3

Proof of principle for epitope-focused vaccine design

Bruno E. Correia, John T. Bates, Rebecca J. Loomis, +24

Nature

VaccinationEpitope-focused Vaccine DesignCross-protectionVaccine TargetImmunology +4

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

Yuya Nishida, Matthew J. Rardin, Chris Carrico, +8

Molecular Cell

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

Morgane Rolland, Paul T. Edlefsen, Brendan B. Larsen, +40

Nature

VaccinationViral EvolutionGenetic SignaturesVaccine TargetHuman Retrovirus +8

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Mihai L. Azoitei, Bruno E. Correia, Yih-En Andrew Ban, +10

Science

EngineeringProtein AssemblyStructural BioinformaticsMolecular BiologyProtein Scaffold +17

Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

Bruno E. Correia, Yih-En Andrew Ban, Margaret A. Holmes, +15

Structure

VaccinationMedicineVaccine TargetImmunologyEpitope-scaffolds Allows Induction +9

Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial

Paul T. Edlefsen, Morgane Rolland, Tomer Hertz, +13

PLoS Computational Biology

VaccinationVaccine DevelopmentVaccine TargetHuman RetrovirusImmunology +13

Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development

Sowmya Sampath, Chris Carrico, Joel H. Janes, +7

PLoS Pathogens

Glycan MaskingImmunologyGlycobiologyMolecular BiologyImmunotherapy +16

Histone malonylation is regulated by SIRT5 and KAT2A

Ran Zhang, Joanna Bons, Grace Scheidemantle, +8

iScience

Histone ModificationsEpigenetic ChangeGeneticsMolecular BiologyEpigenetics +14