Concepedia

Multiscale Pharmacodynamic Modeling

Multiscale Pharmacodynamic Modeling is a computational and mathematical framework that integrates dynamic drug-response relationships across multiple biological scales—from molecular and cellular levels to tissue and organism-wide effects—to characterize and predict the temporal and spatial features of drug action within complex physiological systems.

19

Publications

1.2K

Citations

79

Authors

44

Institutions

Publications per year

2017–2026

8

Parents

Publications

19

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

Frontiers in Physiology · 2011 · 206 citations · Full text

, , +14

Multiscale Modelling of Fluid and Drug Transport in Vascular Tumours

Rebecca J. Shipley, S. Jonathan Chapman · Bulletin of Mathematical Biology · 2010 · 157 citations

, , +16

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Aman P. Singh, Xirong Zheng, Xiefan Lin‐Schmidt et al. · mAbs · 2019 · 113 citations · Full text

, , +17

Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy

Cornelius Cilliers, Hans Guo, Jianshan Liao et al. · The AAPS Journal · 2016 · 112 citations

, , +17

Multidimensional Pharmacokinetic Models Applied to the Design of Drug-Eluting Stents

Paolo Zunino · Cardiovascular Engineering An International Journal · 2004 · 86 citations · Full text

, , +12

1–5 of 19

Authors

79

  1. PZ
    Paolo Zunino

    Politecnico di Milano, Italy

    2 publications · 121 citations

    2

    h-index

  2. ZC
    Zhiwei Cao

    Tongji University, China

    1 publications · 19 citations

    1

    h-index

  3. ME
    Marie E. Rognes

    Simula Research Laboratory, Norway

    1 publications · 22 citations

    1

    h-index

  4. AZ
    Alice Zong

    Janssen (United States), United States

    1 publications · 113 citations

    1

    h-index

  5. XZ
    Xirong Zheng

    University of Kentucky, United States

    1 publications · 113 citations

    1

    h-index

1–5 of 79

Institutions

44

  1. Tongji University

    Shanghai, China

    1 h-index

    2 publications

    38 citations

  2. University of Michigan

    Ann Arbor, United States

    1 h-index

    5 publications

    560 citations

  3. Australian Institute for Musculoskeletal Science

    Saint Albans, Australia

    1 h-index

    1 publications

    55 citations

  4. Janus Biotherapeutics (United States)

    Wellesley, United States

    1 h-index

    7 publications

    791 citations

  5. Université de Montréal

    Montreal, Canada

    1 h-index

    1 publications

    22 citations

  6. Los Alamos National Laboratory

    Los Alamos, United States

    1 h-index

    1 publications

    60 citations

  7. Bayer (Germany)

    Leverkusen, Germany

    1 h-index

    2 publications

    20 citations

  8. Akershus University Hospital

    Lillestrøm, Norway

    1 h-index

    1 publications

    22 citations

1–8 of 44

Venues

  1. Frontiers in Physiology

    2 publications · 218 citations

    2

    h-index

  2. CPT Pharmacometrics & Systems Pharmacology

    PSP · 2 publications · 80 citations

    2

    h-index

  3. Viruses

    2 publications · 33 citations

    2

    h-index

  4. Molecules

    1 publications · 19 citations

    1

    h-index

  5. Cancer Research

    1 publications · 22 citations

    1

    h-index

1–5