First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With Advanced <i>KRAS</i>^<i>G12C</i> Solid Tumors (KRYSTAL-1)

Sai‐Hong Ignatius Ou, Pasi A. Jänne, Ticiana Leal, +11

Journal of Clinical Oncology

Improved Tumor Penetration and Single-Cell Targeting of Antibody–Drug Conjugates Increases Anticancer Efficacy and Host Survival

Cornelius Cilliers, Bruna Menezes, Ian Nessler, +2

Cancer Research

Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy

Cornelius Cilliers, Hans Guo, Jianshan Liao, +2

The AAPS Journal

Immunocytochemical TechniquePharmacokinetic ModelingMedicineImmunologyAntibody Engineering +7

Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance

Cornelius Cilliers, Ian Nessler, Nikolas Christodolu, +1

Molecular Pharmaceutics

99O_PR KRYSTAL-1: Activity and preliminary pharmacodynamic (PD) analysis of adagrasib (MRTX849) in patients (Pts) with advanced non–small cell lung cancer (NSCLC) harboring KRASG12C mutation

G.J. Riely, S-H.I. Ou, Igor I. Rybkin, +15

Journal of Thoracic Oncology

MedicinePharmacologyPathologyCancer TreatmentCancer Genetics +5

Computational transport analysis of antibody-drug conjugate bystander effects and payload tumoral distribution: implications for therapy

Eshita Khera, Cornelius Cilliers, Sumit Bhatnagar, +1

Molecular Systems Design & Engineering

EngineeringComputational ModelPayload Tumoral DistributionImmunologyImmunotherapy +14

Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping

Eshita Khera, Cornelius Cilliers, Michael D. Smith, +7

Neoplasia

NanotherapeuticsPenetration DistanceEngineeringImmunotherapeuticsBiomedical Engineering +20

Residualization Rates of Near-Infrared Dyes for the Rational Design of Molecular Imaging Agents

Cornelius Cilliers, Jianshan Liao, Lydia Atangcho, +1

Molecular Imaging and Biology

Near-infrared DyesEngineeringPhotochemistryChemical ImageBiomedical Imaging +8

Multichannel Imaging to Quantify Four Classes of Pharmacokinetic Distribution in Tumors

Sumit Bhatnagar, Emily Deschenes, Jianshan Liao, +2

Journal of Pharmaceutical Sciences

Multichannel ImagingPharmacokinetic DistributionEngineeringOncologic ImagingMedical Imaging +8

An Agent-Based Systems Pharmacology Model of the Antibody-Drug Conjugate Kadcyla to Predict Efficacy of Different Dosing Regimens

Bruna Menezes, Cornelius Cilliers, Timothy Wessler, +2

The AAPS Journal

Systems PharmacologyMedicinal ChemistryImmunologyPharmacologyDifferent Dosing Regimens +8