Mendelian Randomization

Mendelian Randomization is a methodological approach in genetic epidemiology that uses genetic variants as instrumental variables to infer causal relationships between modifiable exposures and outcomes by leveraging the random allocation of alleles at conception.

2.6K

Publications

234.2K

Citations

14K

Authors

2.8K

Institutions

Publications per year

2017–2026

2.3K

Variants

Parents

Genetic EpidemiologyStatistical Genetics

Children

Bidirectional Mendelian RandomizationColocalization AnalysisDirectional PleiotropyGenetic InstrumentsHeterogeneity TestingHorizontal PleiotropyIndividual-level Data Mendelian RandomizationInstrumental Variable AnalysisInverse Variance Weighted EstimationLeave-one-out Analysis

Publications

2.6K

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden, George Davey Smith, Stephen Burgess · International Journal of Epidemiology · 2015 · 10.6K citations · Full text

Public Health, Biostatistics, Genetics +15

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden, George Davey Smith, Philip Haycock et al. · Genetic Epidemiology · 2016 · 9.6K citations · Full text

Life Sciences, Biostatistics, Genetics +12

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck, Chia‐Yen Chen, Benjamin M. Neale et al. · Nature Genetics · 2018 · 9.2K citations

Public Health, Biostatistics, Genetics +12

The MR-Base platform supports systematic causal inference across the human phenome

Gibran Hemani, Jie Zheng, Benjamin Elsworth et al. · eLife · 2018 · 8.4K citations · Full text

Life Sciences, Biostatistics, Genetics +16

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Stephen Burgess, Adam S. Butterworth, Simon G. Thompson · Genetic Epidemiology · 2013 · 6.4K citations · Full text

Life Sciences, Biostatistics, Genetics +15

1–5 of 2.6K

Authors

14K

GD
George Davey Smith
University of Bristol, United Kingdom
240 publications · 78.9K citations
92
h-index
SB
Stephen Burgess
University of Cambridge, United Kingdom
166 publications · 73.5K citations
78
h-index
JB
Jack Bowden
University of Bristol, United Kingdom
57 publications · 47.2K citations
40
h-index
SC
Susanna C. Larsson
Karolinska Institutet, Sweden
61 publications · 4.6K citations
40
h-index
NM
Neil M Davies
University of Bristol, United Kingdom
59 publications · 8.9K citations
39
h-index

1–5 of 14K

Institutions

2.8K

1–8 of 2.8K

Venues

International Journal of Epidemiology
121 publications · 41.7K citations
62
h-index
PLoS Medicine
42 publications · 6.8K citations
39
h-index
Nature Communications
46 publications · 7.6K citations
36
h-index
BMC Medicine
48 publications · 3.1K citations
32
h-index
Frontiers in Immunology
77 publications · 3K citations
31
h-index

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