Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

A global reference for human genetic variation

Richard Durbin, Peter Donnelly, Paul Flicek et al. · Nature · 2015 · 20K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden, George Davey Smith, Stephen Burgess · International Journal of Epidemiology · 2015 · 10.6K citations · Full text

Public Health, Biostatistics, Genetics +15

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden, George Davey Smith, Philip Haycock et al. · Genetic Epidemiology · 2016 · 9.6K citations · Full text

Life Sciences, Biostatistics, Genetics +12

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Stephen Burgess, Adam S. Butterworth, Simon G. Thompson · Genetic Epidemiology · 2013 · 6.4K citations · Full text

Life Sciences, Biostatistics, Genetics +15

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

George Davey Smith, Shah Ebrahim · International Journal of Epidemiology · 2003 · 6.4K citations

Life Sciences, Biostatistics, Genetics +15