Concepedia

Horizontal Pleiotropy

Horizontal Pleiotropy is a form of genetic pleiotropy in which a genetic variant influences multiple traits through biologically distinct pathways, thereby violating the exclusion restriction assumption required for valid causal inference in Mendelian randomization.

186

Publications

30.3K

Citations

1.1K

Authors

361

Institutions

Publications per year

2017–2026

182

Parents

Publications

186

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck, Chia‐Yen Chen, Benjamin M. Neale et al. · Nature Genetics · 2018 · 9.2K citations

, , +12

The MR-Base platform supports systematic causal inference across the human phenome

Gibran Hemani, Jie Zheng, Benjamin Elsworth et al. · eLife · 2018 · 8.4K citations · Full text

, , +16

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

Gibran Hemani, Kate Tilling, George Davey Smith · PLoS Genetics · 2017 · 2.8K citations · Full text

, , +16

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

Jean Morrison, Nicholas Knoblauch, Joseph Marcus et al. · Nature Genetics · 2020 · 618 citations · Full text

, , +14

Genetic drug target validation using Mendelian randomisation

Amand F. Schmidt, Chris Finan, María Gordillo‐Marañón et al. · Nature Communications · 2020 · 605 citations · Full text

, , +17

1–5 of 186

Authors

1.1K

  1. GD
    George Davey Smith

    University of Bristol, United Kingdom

    15 publications · 12.4K citations

    15

    h-index

  2. GH
    Gibran Hemani

    University of Bristol, United Kingdom

    8 publications · 11.8K citations

    8

    h-index

  3. JB
    Jack Bowden

    University of Bristol, United Kingdom

    6 publications · 8.7K citations

    6

    h-index

  4. KT
    Kate Tilling

    University of Bristol, United Kingdom

    6 publications · 3.2K citations

    6

    h-index

  5. TR
    Tom R. Gaunt

    University of Bristol, United Kingdom

    5 publications · 8.8K citations

    5

    h-index

1–5 of 1.1K

Institutions

361

  1. University of Bristol

    Bristol, United Kingdom

    19 h-index

    112 publications

    175.3K citations

  2. Sun Yat-sen University

    Guangzhou, China

    9 h-index

    43 publications

    1.5K citations

  3. Karolinska Institutet

    Stockholm, Sweden

    8 h-index

    13 publications

    572 citations

  4. Medical Research Council

    London, United Kingdom

    8 h-index

    51 publications

    162K citations

  5. Central South University

    Changsha, China

    8 h-index

    25 publications

    606 citations

  6. Peking University

    Beijing, China

    7 h-index

    23 publications

    836 citations

  7. Jilin University

    Changchun, China

    7 h-index

    39 publications

    666 citations

  8. University of Hong Kong

    Pok Fu Lam, Hong Kong

    6 h-index

    14 publications

    339 citations

1–8 of 361

Venues

  1. Frontiers in Endocrinology

    11 publications · 326 citations

    11

    h-index

  2. Frontiers in Genetics

    9 publications · 249 citations

    9

    h-index

  3. Nature Communications

    8 publications · 1.3K citations

    8

    h-index

  4. Frontiers in Immunology

    8 publications · 414 citations

    8

    h-index

  5. Scientific Reports

    7 publications · 210 citations

    7

    h-index

1–5