Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden, George Davey Smith, Stephen Burgess · International Journal of Epidemiology · 2015 · 10.2K citations · Full text

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden, George Davey Smith, Philip Haycock et al. · Genetic Epidemiology · 2016 · 9.2K citations · Full text

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck, Chia‐Yen Chen, Benjamin M. Neale et al. · Nature Genetics · 2018 · 8.8K citations · Full text

Linkage Disequilibrium, Epidemiology, Genotype-phenotype Association +13

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

George Davey Smith, Shah Ebrahim · International Journal of Epidemiology · 2003 · 6.2K citations

Reverse Causation, Observational Epidemiology, Genetics +21

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Stephen Burgess, Adam S. Butterworth, Simon G. Thompson · Genetic Epidemiology · 2013 · 6.2K citations · Full text

Genetics, Polygenic Risk, Genetic Epidemiology +28