Concepedia

Pleiotropy Analysis

Pleiotropy Analysis is a quantitative genetic method that identifies and characterizes the influence of a single genetic variant on multiple phenotypic traits, distinguishing it from univariate trait analyses by explicitly modeling shared genetic effects across traits.

431

Publications

38.3K

Citations

2.6K

Authors

955

Institutions

Publications per year

2017–2026

279

Parents

Publications

431

The MR-Base platform supports systematic causal inference across the human phenome

Gibran Hemani, Jie Zheng, Benjamin Elsworth et al. · eLife · 2018 · 8.4K citations · Full text

, , +16

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

Gibran Hemani, Kate Tilling, George Davey Smith · PLoS Genetics · 2017 · 2.8K citations · Full text

, , +16

A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe, Sven Stringer, Oleksandr Frei et al. · Nature Genetics · 2019 · 1.5K citations · Full text

, , +17

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

Qingyuan Zhao, Jingshu Wang, Gibran Hemani et al. · The Annals of Statistics · 2020 · 797 citations · Full text

, , +14

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

Sang Lee, Jian Yang, Michael E. Goddard et al. · Bioinformatics · 2012 · 737 citations · Full text

, , +17

1–5 of 431

Authors

2.6K

  1. GD
    George Davey Smith

    University of Bristol, United Kingdom

    9 publications · 11.8K citations

    9

    h-index

  2. HD
    Hong‐Wen Deng

    Hunan Normal University, China

    8 publications · 203 citations

    7

    h-index

  3. JB
    John Blangero

    Texas Biomedical Research Institute, United States

    6 publications · 199 citations

    6

    h-index

  4. GH
    Gibran Hemani

    University of Bristol, United Kingdom

    6 publications · 12.4K citations

    6

    h-index

  5. PX
    Peng Xu

    Xi'an Jiaotong University, China

    5 publications · 260 citations

    5

    h-index

1–5 of 2.6K

Institutions

955

  1. University of Bristol

    Bristol, United Kingdom

    18 h-index

    94 publications

    174K citations

  2. The University of Queensland

    Brisbane, Australia

    15 h-index

    33 publications

    14.3K citations

  3. Harvard University

    Cambridge, United States

    14 h-index

    54 publications

    2.3K citations

  4. Karolinska Institutet

    Stockholm, Sweden

    13 h-index

    36 publications

    1.5K citations

  5. Massachusetts General Hospital

    Boston, United States

    12 h-index

    21 publications

    2.4K citations

  6. University College London

    London, United Kingdom

    11 h-index

    67 publications

    10.5K citations

  7. Broad Institute

    Cambridge, United States

    11 h-index

    19 publications

    2.2K citations

  8. University of Michigan

    Ann Arbor, United States

    11 h-index

    22 publications

    2.2K citations

1–8 of 955

Venues

  1. Frontiers in Genetics

    15 publications · 481 citations

    15

    h-index

  2. Frontiers in Endocrinology

    12 publications · 349 citations

    12

    h-index

  3. Genetic Epidemiology

    14 publications · 894 citations

    12

    h-index

  4. Genetics

    12 publications · 1.1K citations

    12

    h-index

  5. Evolution

    12 publications · 521 citations

    12

    h-index

1–5