Concepedia

Directional Pleiotropy

Directional Pleiotropy is a type of pleiotropic effect in which genetic variants influence multiple phenotypic traits in a consistent, non-random direction, thereby violating the exclusion restriction assumption in Mendelian randomization and potentially biasing causal effect estimates.

46

Publications

9.5K

Citations

245

Authors

189

Institutions

Publications per year

2017–2026

30

Parents

Publications

46

Interpreting findings from Mendelian randomization using the MR-Egger method

Stephen Burgess, Simon G. Thompson · European Journal of Epidemiology · 2017 · 4.8K citations · Full text

, , +13

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

Jack Bowden, Fabiola Del Greco M, Cosetta Minelli et al. · International Journal of Epidemiology · 2016 · 1.7K citations · Full text

, , +13

Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects

Haoran Xue, Xiaotong Shen, Wei Pan · The American Journal of Human Genetics · 2021 · 372 citations · Full text

, , +12

Pleiotropic scaling of gene effects and the ‘cost of complexity’

Günter P. Wagner, Jane P. Kenney‐Hunt, Mihaela Pavličev et al. · Nature · 2008 · 244 citations

, , +17

Two steps forward, one step back: the pleiotropic effects of favoured alleles

Sarah P. Otto · Proceedings of the Royal Society B Biological Sciences · 2004 · 218 citations

, , +11

1–5 of 46

Authors

245

  1. YH
    Young Ho Lee

    Korea University, South Korea

    4 publications · 112 citations

    4

    h-index

  2. SB
    Sang‐Cheol Bae

    Hanyang University Seoul Hospital, South Korea

    3 publications · 97 citations

    3

    h-index

  3. YQ
    Yu Qian

    Zhejiang Chinese Medical University, China

    2 publications · 37 citations

    2

    h-index

  4. AS
    Andrew Singleton

    National Institute on Aging, United States

    2 publications · 266 citations

    2

    h-index

  5. SB
    Stephen Burgess

    University of Cambridge, United Kingdom

    2 publications · 4.9K citations

    2

    h-index

1–5 of 245

Institutions

189

  1. Korea University

    Seoul, South Korea

    4 h-index

    5 publications

    127 citations

  2. MRC Biostatistics Unit

    Cambridge, United Kingdom

    3 h-index

    3 publications

    6.6K citations

  3. Central South University

    Changsha, China

    3 h-index

    16 publications

    964 citations

  4. Yale University

    New Haven, United States

    3 h-index

    4 publications

    492 citations

  5. Harvard University

    Cambridge, United States

    3 h-index

    9 publications

    181 citations

  6. Hanyang University Seoul Hospital

    Seoul, South Korea

    3 h-index

    3 publications

    97 citations

  7. Sorbonne Université

    Paris, France

    2 h-index

    4 publications

    316 citations

  8. Chinese University of Hong Kong

    Hong Kong, Hong Kong

    2 h-index

    2 publications

    164 citations

1–8 of 189

Venues

  1. Theoretical Population Biology

    TPB · 2 publications · 98 citations

    2

    h-index

  2. International Journal of Epidemiology

    2 publications · 1.8K citations

    2

    h-index

  3. Genetics

    2 publications · 89 citations

    2

    h-index

  4. The American Journal of Human Genetics

    AJHG · 2 publications · 387 citations

    2

    h-index

  5. 2

    h-index

1–5