Concepedia

Mecp2 Function

MeCP2 Function is a molecular regulatory mechanism in neurons that belongs to the class of epigenetic reader functions, distinguished by its specific role in interpreting DNA methylation marks to modulate chromatin structure and gene expression.

848

Publications

85.9K

Citations

4.3K

Authors

1.2K

Institutions

Publications per year

2017–2026

227

Parents

Publications

848

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Ruthie E. Amir, Ignatia B. Van den Veyver, Mimi Wan et al. · Nature Genetics · 1999 · 5K citations

, , +9

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Xinsheng Nan, Huck‐Hui Ng, Colin A. Johnson et al. · Nature · 1998 · 3.4K citations

, , +16

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

Maria H. Chahrour, Sung Yun Jung, Chad A. Shaw et al. · Science · 2008 · 1.8K citations

, , +17

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Jacky Guy, Brian Hendrich, Megan C. Holmes et al. · Nature Genetics · 2001 · 1.6K citations

, , +14

Rett syndrome: Revised diagnostic criteria and nomenclature

Jeffrey L. Neul, Walter E. Kaufmann, Daniel G. Glaze et al. · Annals of Neurology · 2010 · 1.4K citations · Full text

, , +17

1–5 of 848

Authors

4.3K

  1. AB
    Adrian Bird

    University of Edinburgh, United Kingdom

    40 publications · 15.1K citations

    36

    h-index

  2. HY
    Huda Y. Zoghbi

    Baylor College of Medicine, United States

    41 publications · 13.6K citations

    35

    h-index

  3. JL
    Jeffrey L. Neul

    Baylor College of Medicine, United States

    21 publications · 3.8K citations

    20

    h-index

  4. HL
    Helen Leonard

    The Kids Research Institute Australia, Australia

    20 publications · 2.6K citations

    18

    h-index

  5. NL
    Nicoletta Landsberger

    University of Milan, Italy

    18 publications · 1.2K citations

    17

    h-index

1–5 of 4.3K

Institutions

1.2K

  1. Baylor College of Medicine

    Houston, United States

    50 h-index

    392 publications

    80.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    43 h-index

    112 publications

    31.8K citations

  3. University of Edinburgh

    Edinburgh, United Kingdom

    38 h-index

    208 publications

    54.3K citations

  4. Harvard University

    Cambridge, United States

    31 h-index

    137 publications

    37.8K citations

  5. Wellcome Centre for Cell Biology

    Edinburgh, United Kingdom

    30 h-index

    156 publications

    34.8K citations

  6. Neurological Research Institute

    Santa Monica, United States

    29 h-index

    216 publications

    17.8K citations

  7. Inserm

    Paris, France

    28 h-index

    170 publications

    9K citations

  8. Texas Children's Hospital

    Houston, United States

    26 h-index

    206 publications

    16.9K citations

1–8 of 1.2K

Venues

  1. Human Molecular Genetics

    42 publications · 4.7K citations

    32

    h-index

  2. Journal of Neuroscience

    33 publications · 4.2K citations

    32

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 25 publications · 4.5K citations

    24

    h-index

  4. PLoS ONE

    28 publications · 1.5K citations

    22

    h-index

  5. Neurobiology of Disease

    19 publications · 1.7K citations

    18

    h-index

1–5