Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Xinsheng Nan, Huck‐Hui Ng, Colin A. Johnson et al. · Nature · 1998 · 3.4K citations

Histone Modifications, Chromatin, Transcriptional Regulation +13

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Peter Lloyd Jones, Gert Jan C. Veenstra, Paul A. Wade et al. · Nature Genetics · 1998 · 2.7K citations

Histone Modifications, Chromatin, Transcriptional Regulation +14

Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation.

R.Cutler Allen, Huda Y. Zoghbi, A. Moseley et al. · PubMed · 1992 · 1.7K citations

A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: Report of 35 cases

Bengt Hagberg, Jean Aicardi, Karin Ziliotto Dias et al. · Annals of Neurology · 1983 · 1.5K citations

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

Joe Lewis, Richard R. Meehan, William J. Henzel et al. · Cell · 1992 · 1.4K citations

Chromatin, Chromatin Remodeling, Epigenetic Change +12