A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Jacky Guy, Brian Hendrich, Megan C. Holmes, +2

Nature Genetics

Knockout MouseMolecular NeuroscienceMendelian DisorderGenetic DisorderGenetics +10

Reversal of Neurological Defects in a Mouse Model of Rett Syndrome

Jacky Guy, Jian Gan, Jim Selfridge, +2

Science

Neurological DisorderRett SyndromeNeurological DefectsNeurologyNeuropathology +15

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

John P. Thomson, Peter J. Skene, Jim Selfridge, +10

Nature

ChromatinTranscriptional RegulationSystems BiologyChromatin StructureChromatin Remodeling +7

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

Matthew J. Lyst, Robert Ekiert, Daniel H. Ebert, +10

Nature Neuroscience

Signal TransductionMendelian DisorderRett Syndrome MutationsGenetic DisorderGenetics +5

Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice

Catherine B. Millar, Jacky Guy, Owen J. Sansom, +7

Science

Cell type–specific DNA methylation at intragenic CpG islands in the immune system

Aimée M. Deaton, Shaun Webb, Alastair Kerr, +4

Genome Research

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

Rubén Deogracias, Morteza Yazdani, Martijn P. J. Dekkers, +4

Proceedings of the National Academy of Sciences

Gene Expression Analysis Exposes Mitochondrial Abnormalities in a Mouse Model of Rett Syndrome

Skirmantas Kriaučionis, Andrew Paterson, John C. Curtis, +3

Molecular and Cellular Biology

MitophagyRett SyndromeGeneticsMolecular GeneticsDisease Gene Identification +14

Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome

Ulrike A. Nuber, Skirmantas Kriaučionis, Tim Roloff, +8

Human Molecular Genetics

Rett SyndromeGeneticsGlucocorticoidMental RetardationNeuroimmunology +19

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome

Lianne Robinson, Jacky Guy, Leanne C. McKay, +8

Brain

Functional ReversalBrain DevelopmentRett SyndromeGeneticsMotor Development +20