Concepedia

Mda5 Signaling

MDA5 Signaling is a molecular pathway in innate immunity wherein the melanoma differentiation-associated protein 5 (MDA5) detects long double-stranded RNA and initiates a cascade leading to type I interferon production through mitochondrial antiviral-signaling protein (MAVS)-dependent activation of transcription factors.

225

Publications

31.6K

Citations

1.6K

Authors

422

Institutions

Publications per year

2017–2026

115

Variants

Mda5 PathwayMda5-mediated Signaling

Parents

Publications

225

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Hiroki Kato, Osamu Takeuchi, Shintaro Sato et al. · Nature · 2006 · 3.8K citations

, , +12

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Taro Kawai, Ken Takahashi, Shintaro Sato et al. · Nature Immunology · 2005 · 2.5K citations

, , +12

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

Mitsutoshi Yoneyama, Mika Kikuchi, Kanae Matsumoto et al. · The Journal of Immunology · 2005 · 1.7K citations · Full text

, , +17

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh et al. · The Journal of Experimental Medicine · 2008 · 1.6K citations · Full text

, , +16

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

Leonid Gitlin, Winfried Barchet, Susan Gilfillan et al. · Proceedings of the National Academy of Sciences · 2006 · 1.2K citations · Full text

, , +17

1–5 of 225

Authors

1.6K

  1. HK
    Hiroki Kato

    Kyoto University, Japan

    13 publications · 10K citations

    13

    h-index

  2. TF
    Takashi Fujita

    Kyoto University, Japan

    12 publications · 8.9K citations

    12

    h-index

  3. SA
    Shizuo Akira

    The University of Osaka, Japan

    10 publications · 12.5K citations

    10

    h-index

  4. MC
    Marco Colonna

    Washington University in St. Louis, United States

    7 publications · 2.2K citations

    7

    h-index

  5. OT
    Osamu Takeuchi

    The University of Osaka, Japan

    7 publications · 9.6K citations

    7

    h-index

1–5 of 1.6K

Institutions

422

  1. Kyoto University

    Kyoto, Japan

    15 h-index

    51 publications

    20.9K citations

  2. Washington University in St. Louis

    St Louis, United States

    13 h-index

    41 publications

    10.5K citations

  3. The University of Osaka

    Osaka, Japan

    13 h-index

    42 publications

    49.1K citations

  4. University of Bonn

    Bonn, Germany

    12 h-index

    60 publications

    4.7K citations

  5. Ludwig-Maximilians-Universität München

    Munich, Germany

    10 h-index

    46 publications

    3.1K citations

  6. Icahn School of Medicine at Mount Sinai

    New York, United States

    9 h-index

    20 publications

    3.2K citations

  7. University Hospital Bonn

    Bonn, Germany

    9 h-index

    29 publications

    1.7K citations

  8. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    53 publications

    3.7K citations

1–8 of 422

Venues

  1. Journal of Virology

    JVI · 19 publications · 2.8K citations

    19

    h-index

  2. The Journal of Immunology

    JI · 15 publications · 3.1K citations

    14

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 3.3K citations

    10

    h-index

  4. Frontiers in Immunology

    9 publications · 263 citations

    9

    h-index

  5. PLoS Pathogens

    8 publications · 918 citations

    8

    h-index

1–5