Concepedia

Mammalian Display

Mammalian Display is an in vitro cell-surface display technology in antibody engineering that uses genetically modified mammalian cells to express and present antibodies or antibody fragments on their plasma membrane, thereby enabling the selection and optimization of candidates in a near-native folding and post-translational modification context.

14

Publications

590

Citations

110

Authors

31

Institutions

Publications per year

2017–2026

9

Parents

Children

Publications

14

High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis

Derek M. Mason, Cédric R. Weber, Cristina Parola et al. · Nucleic Acids Research · 2018 · 87 citations · Full text

, , +17

Mammalian cell display for the discovery and optimization of antibody therapeutics

Peter M. Bowers, Robert A. Horlick, Marilyn R. Kehry et al. · Methods · 2013 · 78 citations

, , +14

Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets

Zachary R. Crook, Gregory P. Sevilla, Della Friend et al. · Nature Communications · 2017 · 76 citations · Full text

, , +13

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

Michael R. Dyson, Edward W. Masters, Deividas Pazeraitis et al. · mAbs · 2020 · 67 citations · Full text

, , +17

Mammalian Cell Display for Antibody Engineering

Mitchell Ho, Ira Pastan · Methods in molecular biology · 2008 · 66 citations · Full text

, , +14

1–5 of 14

Authors

110

  1. KP
    Kothai Parthiban

    University of Cambridge, United Kingdom

    2 publications · 124 citations

    2

    h-index

  2. RA
    Rachael A. Leah

    Universidad de Costa Rica, Costa Rica

    2 publications · 124 citations

    2

    h-index

  3. JM
    John McCafferty

    University of Cambridge, United Kingdom

    2 publications · 124 citations

    2

    h-index

  4. MR
    Michael R. Dyson

    University of Cambridge, United Kingdom

    2 publications · 124 citations

    2

    h-index

  5. RL
    Rajika L. Perera

    University of Cambridge, United Kingdom

    2 publications · 124 citations

    2

    h-index

1–5 of 110

Institutions

31

  1. ETH Zurich

    Zurich, Switzerland

    2 h-index

    23 publications

    961 citations

  2. Fred Hutch Cancer Center

    Seattle, United States

    1 h-index

    11 publications

    836 citations

  3. Centre hospitalier de l'Université Laval

    Québec, Canada

    1 h-index

    1 publications

    31 citations

  4. University of Basel

    Basel, Switzerland

    1 h-index

    1 publications

    22 citations

  5. SIB Swiss Institute of Bioinformatics

    Lausanne, Switzerland

    1 h-index

    2 publications

    44 citations

  6. AnaBios (United States)

    San Diego, United States

    1 h-index

    1 publications

    78 citations

  7. University of Geneva

    Geneva, Switzerland

    1 h-index

    1 publications

    22 citations

  8. Karolinska Institutet

    Stockholm, Sweden

    1 h-index

    2 publications

    44 citations

1–8 of 31

Venues

  1. Journal of Biological Chemistry

    JBC · 2 publications · 57 citations

    2

    h-index

  2. mAbs

    2 publications · 124 citations

    2

    h-index

  3. Cell Reports

    1 publications · 22 citations

    1

    h-index

  4. Zoo Biology

    1 publications · 10 citations

    1

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 1 publications · 31 citations

    1

    h-index

1–5