Concepedia

Combinatorial Antibody Engineering

Combinatorial Antibody Engineering is a methodological framework in molecular biotechnology that enables the systematic generation and selection of diverse antibody variants through the recombination of variable gene segments, phage or yeast display technologies, and high-throughput screening to identify antigen-specific binders with tailored functional properties.

128

Publications

8.8K

Citations

797

Authors

206

Institutions

Publications per year

2017–2026

27

Parents

Publications

128

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides 1 1Edited by I. A. Wilson

Achim Knappik, Liming Ge, Annemarie Honegger et al. · Journal of Molecular Biology · 2000 · 735 citations

, , +16

Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

Angray S. Kang, Carlos F. Barbas, Kim D. Janda et al. · Proceedings of the National Academy of Sciences · 1991 · 414 citations

, , +17

Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem.

Carlos F. Barbas, Jim D. Bain, Denise Hoekstra et al. · Proceedings of the National Academy of Sciences · 1992 · 374 citations

, , +17

Expression and assembly of a fully active antibody in algae

Stephen P. Mayfield, Scott Franklin, Richard A. Lerner · Proceedings of the National Academy of Sciences · 2003 · 342 citations

, , +17

Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries

Eskil Söderlind, Leif Strandberg, Pernilla Jirholt et al. · Nature Biotechnology · 2000 · 335 citations

, , +14

1–5 of 128

Authors

797

  1. RA
    Richard A. Lerner

    Scripps Research Institute, United States

    13 publications · 1.6K citations

    12

    h-index

  2. CF
    Carlos F. Barbas

    Scripps Research Institute, United States

    7 publications · 1.5K citations

    7

    h-index

  3. DR
    Dennis R. Burton

    Scripps Research Institute, United States

    6 publications · 842 citations

    6

    h-index

  4. GW
    Greg Winter

    MRC Laboratory of Molecular Biology, United Kingdom

    5 publications · 348 citations

    5

    h-index

  5. KD
    Kim D. Janda

    Scripps Research Institute, United States

    5 publications · 861 citations

    5

    h-index

1–5 of 797

Institutions

206

  1. Scripps Research Institute

    San Diego, United States

    18 h-index

    111 publications

    14.3K citations

  2. MorphoSys (Germany)

    Planegg, Germany

    5 h-index

    35 publications

    10.3K citations

  3. Lund University

    Lund, Sweden

    4 h-index

    13 publications

    2K citations

  4. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    4 h-index

    10 publications

    705 citations

  5. University of Zurich

    Zurich, Switzerland

    3 h-index

    6 publications

    2K citations

  6. University of Sheffield

    Sheffield, United Kingdom

    3 h-index

    10 publications

    763 citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    12 publications

    310 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    14 publications

    866 citations

1–8 of 206

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 2.1K citations

    14

    h-index

  2. Journal of Molecular Biology

    JMB · 9 publications · 1.6K citations

    9

    h-index

  3. Nature Biotechnology

    6 publications · 730 citations

    6

    h-index

  4. Journal of Immunological Methods

    5 publications · 189 citations

    5

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 4 publications · 196 citations

    4

    h-index

1–5